지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Journal of the Korean Surgical Society Vol.85 No.2
- 발행연도
- 2013.8
- 수록면
- 51 - 57 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Tissue adhesion is a well-known postsurgical phenomenon, causing pain, functional obstruction, and difficult reoperative surgery. To overcome these problems, various synthetic and natural polymer membranes have been developed as postoperative tissue adhesion barriers. However, limitation in their use has hindered its actual application. We prepared a hyaluronate membrane (HM) to evaluate its efficacy and safety as an adhesion barrier compared to a commercialized product (Interceed, Ethicon).
Methods: To evaluate the antiadhesion effect, a cecum-abdominal wall abrasion model was adopted in a rabbit. The denuded cecum was covered by Interceed or HM or neither and apposed to the abdominal wall (each, n = 10). Four weeks after surgery, the level of adhesion was graded. Acute and chronic toxicity of the three groups were also evaluated.
Results: Blood samples drawn to evaluate acute toxicity at postoperative day 3 and 7 showed no significant difference among the three groups. The grade and area of adhesion were significantly lower in the HM compared to those of the control and Interceed at four weeks after surgery. Histologic evaluations, which was carried out to estimate tissue reactions at the site of application, as well as to assess chronic toxicity for the major organs, were not significantly different in the three groups.
Conclusion: This study showed that the antiadhesion efficacy of HM was superior to commercialized antiadhesion membrane, Interceed. Low inflammatory response and nontoxicity were also demonstrated. From these results, we suggest that the HM is a good candidate as a tissue adhesion barrier.
Methods: To evaluate the antiadhesion effect, a cecum-abdominal wall abrasion model was adopted in a rabbit. The denuded cecum was covered by Interceed or HM or neither and apposed to the abdominal wall (each, n = 10). Four weeks after surgery, the level of adhesion was graded. Acute and chronic toxicity of the three groups were also evaluated.
Results: Blood samples drawn to evaluate acute toxicity at postoperative day 3 and 7 showed no significant difference among the three groups. The grade and area of adhesion were significantly lower in the HM compared to those of the control and Interceed at four weeks after surgery. Histologic evaluations, which was carried out to estimate tissue reactions at the site of application, as well as to assess chronic toxicity for the major organs, were not significantly different in the three groups.
Conclusion: This study showed that the antiadhesion efficacy of HM was superior to commercialized antiadhesion membrane, Interceed. Low inflammatory response and nontoxicity were also demonstrated. From these results, we suggest that the HM is a good candidate as a tissue adhesion barrier.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Yang HY / 1997 / A clinical analysis of intestinal obstruction in the adult / J Korean Surg Soc 52 : 335 ~ 342
2. [학술지(정기간행물)] - Almeida OD Jr / 1997 / Conscious pain mapping / J Am Assoc Gynecol Laparosc 4 : 587 ~ 590
3. [단행본] - Marana R / 2000 / Infertility and adhesions. In: DiZerega GS. Peritoneal surgery / Springer-Verlag : 329 ~ 333
4. [학술지(정기간행물)] - Lee WJ / 1995 / The factors influencing the treatment for the mechanical intestinal obstruction due to adhesion / J Korean Surg Soc 49 : 192 ~ 203
5. [학술지(정기간행물)] - Falk K / 2001 / Reduction of experimental adhesion formation by inhibition of plasminogen activator inhibitor type 1 / Br J Surg 88 : 286 ~ 289
2. [학술지(정기간행물)] - Almeida OD Jr / 1997 / Conscious pain mapping / J Am Assoc Gynecol Laparosc 4 : 587 ~ 590
3. [단행본] - Marana R / 2000 / Infertility and adhesions. In: DiZerega GS. Peritoneal surgery / Springer-Verlag : 329 ~ 333
4. [학술지(정기간행물)] - Lee WJ / 1995 / The factors influencing the treatment for the mechanical intestinal obstruction due to adhesion / J Korean Surg Soc 49 : 192 ~ 203
5. [학술지(정기간행물)] - Falk K / 2001 / Reduction of experimental adhesion formation by inhibition of plasminogen activator inhibitor type 1 / Br J Surg 88 : 286 ~ 289
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-510-002955051