지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 2 - 7 (6page)
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Background: The efficacy of two artificial tears, carboxymethylcellulose (CMC) and hyaluronate (HA), was com-pared in the treatment of patients with dry eye disease.Methods: We conducted a systematic review and meta-analysis on randomized controlled trials in the PubMed, Embase, Cochrane Library, and ClinicalTrials.gov databases. The efficacy was compared in terms of the mean change from baseline in tear break-up time. The meta-analysis was conducted using both random and fixed effect models. The quality of the selected studies was assessed for risk of bias.Results: Five studies were included involving 251 participants. Random effect model meta-analysis showed no sig-nificant difference between CMC and HA in treating dry eye disease (pooled standardized mean difference [SMD]=-0.452; 95% confidence interval [CI], -0.911 to 0.007; P=0.053). In contrast, fixed effect model meta-analysis revealed significant improvements in the CMC group when compared to the HA group (pooled SMD=-0.334; 95% CI, -0.588 to -0.081; P=0.010).Conclusion: The efficacy of CMC appeared to be better than that of HA in treating dry eye disease, although meta-analysis results were not statistically significant. Further research is needed to better elucidate the difference in effi-cacy between CMC and HA in treating dry eye disease.
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참고문헌 (22)
참고문헌 신청
/ / Safety and efficacy of carboxymethylcellulose for ocular surface integrity in symptomatic dry eye
/ / Study to compare the efficacy and safety of two nonpreserved artificial tears for the treatment of dry eye signs and symptoms
/ 2007 / The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop / Ocul Surf 5 :
Aragona P / 2002 / Long term treatment with sodium hyaluronate-containing artificial tears reduces ocular surface damage in patients with dry eye / Br J Ophthalmol 86 : 181 ~
Baudouin C / 2012 / Randomized, phase III study comparing osmoprotective carboxymethylcellulose with sodium hyaluronate in dry eye disease / Eur J Ophthalmol 22 : 751 ~ 761
/ / Study to compare the efficacy and safety of two nonpreserved artificial tears for the treatment of dry eye signs and symptoms
/ 2007 / The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop / Ocul Surf 5 :
Aragona P / 2002 / Long term treatment with sodium hyaluronate-containing artificial tears reduces ocular surface damage in patients with dry eye / Br J Ophthalmol 86 : 181 ~
Baudouin C / 2012 / Randomized, phase III study comparing osmoprotective carboxymethylcellulose with sodium hyaluronate in dry eye disease / Eur J Ophthalmol 22 : 751 ~ 761
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