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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.8
- 수록면
- 84 - 89 (6page)
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Purpose: Nuclear Factor-κB p65 (NF-κB p65) and nuclear Factor-κB1 p50 (NF-κB p65) have been shown to play roles in cell proliferation, apoptosis, cytokine production and oncogenesis. This study was designed to investigate the expressions of NF-κB p65 and NF-κB p50 proteins in premalignant lesions and colorectal adenocarcinoma.
Methods: Paraffin sections of 20 normal mucosa specimens, 20 low grade tubular adenoma specimens, 20 high grade tubular adenoma specimens and 64 adenocarcinoma specimens were analyzed immunohistochemically for the expressions of NF-κB p65 and NF-κB p50 proteins.
Results: The expressions of NF-κB p65 and NF-κB p50 proteins were significantly higher in the adenocarcinoma tissue compared with that in the normal mucosa, the low grade tubular adenoma and the high grade tubular adenoma tissues. The frequency of a NF-κB p50 expression was higher in the poorly differentiated histologic grade specimens, in the presence of nodal metastasis and in the high stage specimens. There were significant correlations between the NF-κB p65 and NF-κB p50 proteins.
Conclusion: The expressions of NF-κB p65 and NF-κB p50 proteins may play a role in the pathogenesis of colorectal carcinoma.
Methods: Paraffin sections of 20 normal mucosa specimens, 20 low grade tubular adenoma specimens, 20 high grade tubular adenoma specimens and 64 adenocarcinoma specimens were analyzed immunohistochemically for the expressions of NF-κB p65 and NF-κB p50 proteins.
Results: The expressions of NF-κB p65 and NF-κB p50 proteins were significantly higher in the adenocarcinoma tissue compared with that in the normal mucosa, the low grade tubular adenoma and the high grade tubular adenoma tissues. The frequency of a NF-κB p50 expression was higher in the poorly differentiated histologic grade specimens, in the presence of nodal metastasis and in the high stage specimens. There were significant correlations between the NF-κB p65 and NF-κB p50 proteins.
Conclusion: The expressions of NF-κB p65 and NF-κB p50 proteins may play a role in the pathogenesis of colorectal carcinoma.
목차
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고찰
REFERENCES
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Lind DS / 2001 / Nuclear factor-kappa B is upregulated in colorectal cancer / Surgery 130 : 363 ~ 369
2. [기타자료] - / / 2006 Korean cancer research 2007. Ministry of health and welfare, Korea
3. [학술지(정기간행물)] - Aranha MM / 2007 / NF-kappaB and apoptosis in colorectal tumourigenesis / Eur J Clin Invest 37 : 416 ~ 424
4. [학술지(정기간행물)] - Karin M / 2006 / NF-κB and cancer: mechanism and targets / Mol Carcinogenesis 45 : 355 ~ 361
5. [학술지(정기간행물)] - Xiao CW / 2003 / Resistance of human ovarian cancer cells to tumor necrosis factor alpha is a consequence of nuclear factor kappaB-mediated induction of Fas-associated death domain-like interleukin-1beta- converting enzyme-like inhibitory protein / Endocrinology 144 : 623 ~ 630
2. [기타자료] - / / 2006 Korean cancer research 2007. Ministry of health and welfare, Korea
3. [학술지(정기간행물)] - Aranha MM / 2007 / NF-kappaB and apoptosis in colorectal tumourigenesis / Eur J Clin Invest 37 : 416 ~ 424
4. [학술지(정기간행물)] - Karin M / 2006 / NF-κB and cancer: mechanism and targets / Mol Carcinogenesis 45 : 355 ~ 361
5. [학술지(정기간행물)] - Xiao CW / 2003 / Resistance of human ovarian cancer cells to tumor necrosis factor alpha is a consequence of nuclear factor kappaB-mediated induction of Fas-associated death domain-like interleukin-1beta- converting enzyme-like inhibitory protein / Endocrinology 144 : 623 ~ 630
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UCI(KEPA) : I410-ECN-0101-2013-514-002690968