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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.4
- 수록면
- 267 - 273 (7page)
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Water-soluble fraction (WSF) from edible mushroom hinmogi (Tremella fuciformis) were obtained by water extraction, and polysaccharides in the WSF were separated by ethanol precipitation. The inhibitory effects of the polysaccharides on 3T3-L1 adipocyte differentiation were evaluated by the reduction of peroxisome proliferators-activated receptor γ (PPARγ) translation, triglyceride accumulation, Oil Red-O staining, and expression levels of PPARγ, CCAAT/enhancer binding protein α (C/EBPα), and leptin. The PPARγ translation in 3T3-L1 cells was inhibited by the treatment with polysaccharide precipitated by 80% ethanol (P80) which showed highest inhibitory activity among polysaccharides tested. In addition, treatment of P80 to 3T3-L1 cells significantly inhibited the triglyceride accumulation, Oil Red-O staining, and mRNA expression of PPARγ, C/EBPα, and leptin in a dose-dependent manner. Based upon these results, P80 from edible mushroom hinmogi shows the inhibitory activity on the differentiation of 3T3-L1 adipocytes. Therefore, it might be employed as a potential anti-obesity material.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References
참고문헌 (28)
참고문헌 신청
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2. [학술지(정기간행물)] - Kawada T / 2001 / Biochemical and physiological characteristics of fat cell / J. Nutr. Sci. Vitaminol : 1 ~ 12
3. [학술지(정기간행물)] - Wise LS / 1979 / Participation of one isozyme of cytosolic glycerophosphate dehydrogenase in the adipose conversion of 3T3 cells / J. Biol. Chem (254) : 273 ~ 275
4. [학술지(정기간행물)] - Takahashi N / 2002 / Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferators-activated receptor gamma / J. Biol. Chem 277 : 16906 ~ 16912
5. [학술지(정기간행물)] - Takahashi N / 2002 / Dual action of isoprenols from herbal medicines on both PPARγ and PPARα in 3T3-L1 adipocytes and HepG2 hepatocytes / FEBS Lett 514 : 315 ~ 322
2. [학술지(정기간행물)] - Kawada T / 2001 / Biochemical and physiological characteristics of fat cell / J. Nutr. Sci. Vitaminol : 1 ~ 12
3. [학술지(정기간행물)] - Wise LS / 1979 / Participation of one isozyme of cytosolic glycerophosphate dehydrogenase in the adipose conversion of 3T3 cells / J. Biol. Chem (254) : 273 ~ 275
4. [학술지(정기간행물)] - Takahashi N / 2002 / Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferators-activated receptor gamma / J. Biol. Chem 277 : 16906 ~ 16912
5. [학술지(정기간행물)] - Takahashi N / 2002 / Dual action of isoprenols from herbal medicines on both PPARγ and PPARα in 3T3-L1 adipocytes and HepG2 hepatocytes / FEBS Lett 514 : 315 ~ 322
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UCI(KEPA) : I410-ECN-0101-2013-573-001015340