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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.4
- 수록면
- 274 - 278 (5page)
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초록· 키워드
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Ethanol extracts from the edible mushroom hinmogi (Tremella fuciformis, TF) were used in the investigation of effects on α-glucosidase in vitro and on glucose-uptake in 3T3-L1 mature adipocytes. Addition of the extract significantly inhibited α-glucosidase from small intestine of porcine and of rat (about 42 and 35% of control, respectively), and stimulated glucose uptake (about 100% of control), of which activity was higher than that of maitake (Grifola frondosa) X-fraction, a well known anti-diabetic substance. When the ethanol extracts were further partitioned successively by organic solvents and purified by silica gel chromatography, the non-polar layer (F-7) from hexane layer showed highest stimulatory activity of glucose-uptake among layers tested. The major components of the F-7 were 1-monooleoylglycerol and 1-monopalmitoylglycerol. Our report is the first description of TF with stimulatory activity of glucose-uptake. These results suggest that TF extracts may constitute a new source of glucose transport activator and could be employed as a potential anti-diabetic material for treatment and preventing diabetes.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Akerblom HK / 1998 / Putative environmental factors in Type 1 diabetes / Diabetes Metab. Rev 14 : 31 ~ 67
2. [학술지(정기간행물)] - Karam JH / 1992 / Type II diabetes and syndrome X. Pathogenesis and glycemic management / Endocrinol. Metab. Clin 21 : 329 ~ 350
3. [학술지(정기간행물)] - Genuth S / 1992 / Management of the adult onset diabetic with sulfonylurea drug failure / Endocrinol. Metab. Clin 21 : 351 ~ 370
4. [학술지(정기간행물)] - Day C / 1999 / Thiazolidininediones: A new class of antidiabetic drugs / Diabetic. Med 16 : 179 ~ 192
5. [학술지(정기간행물)] - Murakami C / 1993 / Screening of plant constituents for effect on glucose transport activity in Ehrlich ascites tumor cells / Chem. Pharm. Bull 41 : 2129 ~ 2131
2. [학술지(정기간행물)] - Karam JH / 1992 / Type II diabetes and syndrome X. Pathogenesis and glycemic management / Endocrinol. Metab. Clin 21 : 329 ~ 350
3. [학술지(정기간행물)] - Genuth S / 1992 / Management of the adult onset diabetic with sulfonylurea drug failure / Endocrinol. Metab. Clin 21 : 351 ~ 370
4. [학술지(정기간행물)] - Day C / 1999 / Thiazolidininediones: A new class of antidiabetic drugs / Diabetic. Med 16 : 179 ~ 192
5. [학술지(정기간행물)] - Murakami C / 1993 / Screening of plant constituents for effect on glucose transport activity in Ehrlich ascites tumor cells / Chem. Pharm. Bull 41 : 2129 ~ 2131
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UCI(KEPA) : I410-ECN-0101-2013-573-001015355