지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 1,265 - 1,271 (7page)
이용수
초록· 키워드
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Adlay bran is a waste product previously thought to have no commercial value. Its methanolic extract was fractionated using n-hexane (ABM-Hex), ethyl acetate (ABM-EtOAc), 1-butanol (ABM-BuOH), and water (ABM-H₂O). The ABM-EtOAc fraction exhibited a strongest inhibition against growth of human lung cancer cell A549 and human colorectal carcinoma cells HT-29 and COLO 205. Inhibition of cell cycle progression at G?/G₁ transition, increase of cells at the sub-G1 phase, and DNA ladders were observed in cells treated with ABM-EtOAc. The ABM-BuOH fraction showed the strongest inhibition of proinflammatory cytokines tumor necrosis factor (TNF)-α and interlukin (IL)-1β in stimulated RAW 264.7 macrophages. Further, ABM-EtOAc and ABM-BuOH inhibited cyclooxygenase (COX)-2 expression in A549 and HT-29 carcinoma cells, while COX-1 expression was not affected. These results reveal that both ABM-EtOAc and ABM-BuOH may aid the prevention of cancers and the applications in cancer chemotherapy.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
References
참고문헌 (31)
참고문헌 신청
Yang JH / 2004 / Storage stability of monascal adlay / Food Chem 90:303~309
Laufenberg G / 2003 / Transformation of vegetable waste into value added products: (A) The upgrading concept; (B) practical implementations / Bioresource Technol 87:167~198
Aliotta G / 2000 / Allelochemicals from rue (Ruta graveolens L.) and olive (Olea europaea L.) oil mill waste waters as potential natural pesticides / Curr. Top. Phytochem 3:167~177
Seo WG / 2000 / Inhibitory effects of methanol extract of seeds of Job’s tears (Coix lachryma-jobi L. var. ma-yuen) on nitric oxide and superoxide production in RAW 264.7 macrophages / Immunopharm. Immunot 22:545~554
Kuo CC / 2001 / Antagonism of freeradical- induced damage of adlay seed and its antiproliferative effect in human histolytic lymphoma U937 monocytic cells / J. Agr. Food Chem 49:1564~1570
Laufenberg G / 2003 / Transformation of vegetable waste into value added products: (A) The upgrading concept; (B) practical implementations / Bioresource Technol 87:167~198
Aliotta G / 2000 / Allelochemicals from rue (Ruta graveolens L.) and olive (Olea europaea L.) oil mill waste waters as potential natural pesticides / Curr. Top. Phytochem 3:167~177
Seo WG / 2000 / Inhibitory effects of methanol extract of seeds of Job’s tears (Coix lachryma-jobi L. var. ma-yuen) on nitric oxide and superoxide production in RAW 264.7 macrophages / Immunopharm. Immunot 22:545~554
Kuo CC / 2001 / Antagonism of freeradical- induced damage of adlay seed and its antiproliferative effect in human histolytic lymphoma U937 monocytic cells / J. Agr. Food Chem 49:1564~1570
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UCI(KEPA) : I410-ECN-0101-2013-573-000858458