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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.6
- 수록면
- 808 - 812 (5page)
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The α-glucosidase inhibitory and antioxidant effects of water chestnut (Trapa japonica Flerov.) were assessed to explore its possible use as an anti-diabetic agent. Methanol extracts of the fruit shell and meat of water chestnut were assayed for inhibitory activity against yeast α-glucosidase and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. Effect of fruit shell extract on postprandial glucose response was assessed. Compared with fruit meat, shell extract showed stronger inhibition against α-glucosidase with an IC?? of 273 ㎍/㎖. Oral administration of fruit shell extract (500 ㎎/㎏) significantly lowered the postprandial area under the glucose response curve to starch (1 g/㎏) in streptozotocin (STZ)-induced diabetic rats (p＜0.01). Compared with fruit meat, shell extract showed stronger scavenging activity against DPPH, with an IC?? of 27.1 ㎍/㎖. The results indicate that the fruit shell of water chestnut was effective in controlling postprandial hyperglycemia and exerted an antioxidant effect. Therefore, water chestnut may be useful in treating diabetes.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References
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