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논문 기본 정보

자료유형
학술저널
저자정보
So Young Yu (이화여자대학교) Han Kyoung Ryu (이화여자대학교) Hee Jung Park (제일제당) Young Ju Choi (21C Diabetes and Vascular Research Center) Kap Bum Huh (21C Diabetes and Vascular Research Center) Wha Young Kim (이화여자대학교)
저널정보
한국영양학회 Nutrition Research and Practice Nutrition Research and Practice Vol.1 No.4
발행연도
2007.12
수록면
363 - 370 (8page)

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Single nucleotide polymorphism (SNP) in adiponectin gene has been associated with insulin resistance, diabetes, and cardiovascular disease (CVD). This study was performed to investigate the association of SNP 276G→T at adiponectin gene with CVD risk factors in Korean type 2 diabetes mellitus (DM) patients. The subjects were 351 type 2 DM patients visited a DM clinic in Seoul, and the patients with known CVD were excluded. The adiponectin SNP 276G→T was analyzed and dietary intakes were assessed by a Food Frequency Questionnaire. The prevalence of G/G, G/T, and T/T genotype was 47.6%, 43.3%, and 9.1%, respectively. Male subjects with T/T genotype showed significantly lower level of adiponectin and HDL-cholesterol and significantly higher C-reactive protein (CRP) level compared to G/G and G/T genotypes. In G/G genotype, protein intake was negatively correlated to body weight, BMI, and waist circumference, and there were positive correlation between carbohydrate intake and BMI, waist-hip ratio, and ApoB/apoA-1 ratio in G/T genotype. However, in T/T genotype, there was no significant association between macronutrient intakes and anthropometric and hematological values. In conclusion, CVD risk would be high in type 2 DM patients with T/T genotype, and the association of macronutrient intakes with anthropometric and hematologic factors was different among the three adiponectin genotypes. These results may imply the need for different dietary management regime according to adiponectin genotype to lower CVD complications in Korean type 2 DM patients.

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Abstract
Introduction
Subjects and Methods
Results
Discussion
Literature cited

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UCI(KEPA) : I410-ECN-0101-2013-594-000330707