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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.2
- 수록면
- 126 - 135 (10page)
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Obesity is characterized by increased storage of fatty acids in an adipose tissue and closely associated with the development of insulin resistance and cardiovascular diseases (CVD) through secretion of adipokines. This study was done to compare serum insulin, leptin, adiponectin and high sensitivity C-reactive protein (hs-CRP) levels according to body masss index (BMI) in Korean adult women aged 19 to 50. In addition, we examined the association of BMI, serum lipids and Homa-IR with serum adiponectin, leptin and hs-CRP levels. The subjects were divided into 3 groups by their BMI, normal weight (BMI ≤ 22.9, n = 30), overweight (23.0 ≤ BMI ≤ 24.9, n = 71) and obese group (25.0 ≤ BMI, n = 59). Serum levels of total-cholesterol, TG, and LDL-cholesterol were significantly higher in obese group than in normal weight group. LDL/HDL ratio and AI were significantly higher in obese group than in normal or overweight group. Fasting serum levels of glucose and insulin and Homa-IR as a marker of insulin resistance were significantly higher in obese group than in overweight group. Serum leptin level was significantly higher in obese group while serum adiponectin level was significantly lower in obese group compared to other two groups. hs-CRP was significantly increased in obese group. Correlation data show that serum adiponectin level was positively correlated with serum HDLcholesterol level and was negatively correlated with BMI, WC, TG, LDL-cholesterol, Homa-IR, hs-CRP and leptin. In addition, serum leptin level was positively correlated with BMI, WC, glucose, insulin, Homa-IR and hs-CRP. These results might imply that the regulation of key adipokines such as adiponectin might be a strategy for the prevention or treatment of obesity-associated diseases such as diabetes and CVD. (Korean J Community Nutr 16(1) : 126~135, 2011)
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참고문헌 (57)
참고문헌 신청
1. [학술지(정기간행물)] - Abbasi F / 2006 / Improvements in insulin resistance with weight loss, in contrast to rosiglitazone, are not associated with changes in plasma adiponectin or adiponectin multimeric complexes / Am J Physiol Regul Integr Comp Physiol 290 (1) : 139 ~ 144
2. [학술지(정기간행물)] - Adamczak M / 2003 / Decreased plasma adiponectin concentration in patients with essential hypertension / Am J Hypertens 16 (1) : 72 ~ 75
3. [학술지(정기간행물)] - 안계현 / 2008 / 건강한 소아에서 렙틴 아디포넥틴 비와 인슐린 저항성의 관계 / Korean Journal of Pediatrics 51 (3) : 256 ~ 261
4. [학술지(정기간행물)] - Bastard JP / 2006 / Recent advances in the relationship between obesity, inflammation, and insulin resistance / Eur Cytokine Netw 17 (1) : 4 ~ 12
5. [학술지(정기간행물)] - Berg AH / 2001 / The adipocyte-secreted protein Acrp30 enhances hepatic insulin action / Nat Med 7 (8) : 947 ~ 953
2. [학술지(정기간행물)] - Adamczak M / 2003 / Decreased plasma adiponectin concentration in patients with essential hypertension / Am J Hypertens 16 (1) : 72 ~ 75
3. [학술지(정기간행물)] - 안계현 / 2008 / 건강한 소아에서 렙틴 아디포넥틴 비와 인슐린 저항성의 관계 / Korean Journal of Pediatrics 51 (3) : 256 ~ 261
4. [학술지(정기간행물)] - Bastard JP / 2006 / Recent advances in the relationship between obesity, inflammation, and insulin resistance / Eur Cytokine Netw 17 (1) : 4 ~ 12
5. [학술지(정기간행물)] - Berg AH / 2001 / The adipocyte-secreted protein Acrp30 enhances hepatic insulin action / Nat Med 7 (8) : 947 ~ 953
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