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자료유형
학술저널
저자정보
저널정보
한국영양학회 Nutritional Sciences Nutritional Sciences Vol.9 No.2
발행연도
2006.5
수록면
61 - 67 (7page)

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Green tea has attracted attention with respect to its potential for preventing and treating neurodegenerative disease. The neurotoxin, 6-hydroxydopamine(6-OHDA), was used to produce experimental Parkinson's disease (PD) model. The purpose of this study was to investigate the effects of green tea diet on behavioral changes, striatal dopamine content, and hepatic antioxidant parameters of PD model rats. In this study, we used male Sprague-Dawley rats weighing 200~220g and injected 6-OHDA into the right substantia nigra and medial forebrain bundle of the brain. The supply of green tea diet was started at 2 weeks before 6-OHDA lesion and continually supplied during 0, 2, and 4 weeks after 6-OHDA lesion (GT-0, GT-2, GT-4). Behavioral disturbance was measured by the stepping and d-amphetamine drug-induced rotation tests. Then, we assayed the striatal dopamine content and the hepatic malondialdehyde (MDA), hydrogen peroxide (H₂O₂), and superoxide dismutase (SOD) activity. The percentage of lesioned forepaw to non-lesioned forepaw step scores was the highest in GT-4 group among all groups at both 3 and 4 weeks after 6-OHDA lesion. At 4 weeks after 6-OHDA lesion, the rotation score was the lowest in GT-2 group (p＜0.05). However, increasing rate of the rotation score from 2 to 4 weeks after 6-OHDA lesion was the lowest in GT-4 group. The striatal dopamine content was not significantly different among four groups by green tea diet The hepatic MDA level was the lowest in GT-4 group among four groups. The hepatic SOD activity was increased with the prolongation of green tea diet period These results suggest that green tea diet affects behavioral changes in rats of PD model. It seems that continuous green tea supplementation has an influence on the reduction of behavioral disturbance and the hepatic MDA level. Accordingly, continuous green tea supplementation was recommended for the prevention and treatment of PD. However, further studies are needed to investigate the mechanisms and efficacy of green tea in PD.
#Green tea #Parkinson's disease #Behavioral disturbance #Dopamine #Antioxidant

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
Literature cited

참고문헌 (29)

참고문헌 신청
[학술지(정기간행물)] - / 2004 / Neurological mechanisms of green tea polyphenols in Alzheimers and Parkinsons disease 15 : 506 ~ 516 google schola [학술지(정기간행물)] - / 2005 / Protective effect of green tea polyphenols on the SH SY5Y cells against 6 OHDA induced apoptosis through ROS NO pathway 39 : 682 ~ 695 google schola [학술지(정기간행물)] - / 2003 / Potential therapeutic properties of green tea polyphenols in Parkinsons disease 20 : 711 ~ 721 google schola [학술지(정기간행물)] - / 2004 / Roles of catalase and hydrogen peroxide in green tea polyphenol induced chemopreventive effects 308 : 317 ~ 323 google schola [학술지(정기간행물)] - / 2005 / Zingerone prevents 6 hydroxydopamine induced dopamine depression in mouse striatum and increase superoxide scavenging activity in serum 30 : 325 ~ 332 google schola

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