지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 375 - 383 (9page)
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초록· 키워드
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In the previous report, we have demonstrated that ginsenoside Rc, one of major ginsenosides, is a major component for the restoration for normal growth of worms in cholesterol-deprived medium. In the present study, we further investigated the roles of minor ginsenosides, such as ginsenoside Rh<sub>1</sub> and Rh<sub>2</sub>, ginsenoside metabolites such as compound K (CK), protopanaxadiol (PPD), and protopanaxatriol (PPT) and ginsenoside epimers such as 20(R)-and 20(S)-ginsenoside Rg<sub>3</sub> in cholesterol-deprived medium. We found that ginsenoside Rh<sub>1</sub> almost restored normal growth of worms in cholesterol-deprived medium in F1 generation. However, supplement of ginsenoside Rh2 caused a suppression of worm growths in cholesterol-deprived medium. In addition, CK and PPD also slightly restored normal growth of worms in cholesterol-deprived medium but PPT not. In experiments using ginsenoside epimers, supplement of 20(S)- but not 20(R)-ginsenoside Rg<sub>3</sub> in cholesterol-deprived medium also almost restored worm growth. These results indicate that the absence or presence of carbohydrate component at backbone of ginsenoside, the number of carbohydrate attached at carbon-3, and the position of hydroxyl group at carbon-20 of ginsenoside might plays important roles in restoration of worm growth in cholesterol-deprived medium.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (15)
참고문헌 신청
1. [학술지(정기간행물)] - Tyler VE / 1995 / Herbal remedies / J Pharm Technol 11 : 214 ~ 220
2. [학술지(정기간행물)] - Hieb WF / 1968 / Sterol requirement for reproduction of a free-living nematode / Science 160 : 778 ~ 780
3. [학술지(정기간행물)] - Merris M / 2003 / Sterol effects and sites of sterol accumulation in Caenorhabditis elegans: developmental requirement for 4alpha-methyl sterols / J Lipid Res 44 : 172 ~ 181
4. [학술지(정기간행물)] - Shim YH / 2002 / Role of cholesterol in germ-line development of Caenorhabditis elegans / MOLECULAR REPRODUCTION AND DEVELOPMENT 61 (3) : 358 ~ 366
5. [학술지(정기간행물)] - Kim JH / 2006 / The root-lesion nematode, Pratylenchus subpenetrans, on ginseng (Panax ginseng) in Korea / Nematology 8 : 637 ~ 639
2. [학술지(정기간행물)] - Hieb WF / 1968 / Sterol requirement for reproduction of a free-living nematode / Science 160 : 778 ~ 780
3. [학술지(정기간행물)] - Merris M / 2003 / Sterol effects and sites of sterol accumulation in Caenorhabditis elegans: developmental requirement for 4alpha-methyl sterols / J Lipid Res 44 : 172 ~ 181
4. [학술지(정기간행물)] - Shim YH / 2002 / Role of cholesterol in germ-line development of Caenorhabditis elegans / MOLECULAR REPRODUCTION AND DEVELOPMENT 61 (3) : 358 ~ 366
5. [학술지(정기간행물)] - Kim JH / 2006 / The root-lesion nematode, Pratylenchus subpenetrans, on ginseng (Panax ginseng) in Korea / Nematology 8 : 637 ~ 639
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UCI(KEPA) : I410-ECN-0101-2013-524-000762314