지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2010.11
- 수록면
- 4,053 - 4,058 (6page)
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초록· 키워드
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Bone consists of three types of mechanosensitive cells, namely osteoblast, osteocytes, and osteoclast. Osteoblasts and osteoclasts are specialized cells responsible for bone formation and resorption, respectively. Osteoblasts get trapped into bone matrix to form osteocytes. These cells functionally adapt to external physical forces in concert to maintain homeostasis and mechanical integrity of the bone. Especially, osteroblasts playa central role in bone remodeling by regulating neighboring osteoclasts and differentiating themselves into osteocytes. In this research, we employ two different types of physical stimulations, tensile stress (TS) and electric field (EF), on osteoblasts to investigate the effects of these forces on factors influencing bone remodeling. Our results indicate that osteoblasts are responsive to both TS and EF, showing noticeable upregulation of ALP, BSP, osteopontin (OP), OPG as well as downregulation of RANKL. Since high expression of RANKL is known to promote osteoclast activity for accelerated resorption, TS and EF induced downregulation of RANKL and upregulation of ALP, BSP, OP, and OPG will likely to activate bone formation. Furthermore, TS and EF have shown to up-regulate the expression of DMP-1, promoting the differentiation of osteoblast to osteocyte. Our study confirms that proper external stimulation can strengthen bone remodeling process through ostoeblast activation and osteoclast de-activation.
목차
Abstract
1. 서론
2. 실험 방법
3. 결과
4. 결론 및 토의
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UCI(KEPA) : I410-ECN-0101-2012-550-003944263