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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 479 - 483 (5page)
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The balance between osteoblast-dependent bone formation and osteoclast-dependent bone resorption maintains bone homeostasis. In inflammatory conditions, this balance shifts toward bone resorption, causing osteolytic bone lesions observed in rheumatoid arthritis and periodontitis. A recently discovered family of cytokine IL-17 is widely reported to mediate diverse inflammatory processes. During the last decade, novel roles for IL-17 in skeletal homeostasis have been discovered indicating the potential importance of this cytokine in bone metabolism. This review will summarize and discuss the involvement of IL-17 during bone homeostasis in both physiologic and pathologic conditions. A better understanding of the role of IL-17 in skeletal systems warrants an advance in bone biology, as well as development of therapeutic strategies against bone-lytic diseases, such as rheumatoid arthritis and periodontitis. [BMB Reports 2013; 46(10): 479-483]
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참고문헌 (48)
참고문헌 신청
Kitami, S. / 2010 / IL-17A suppresses the expression of bone resorption-related proteinases and osteoclast differentiation via IL-17RA or IL-17RC receptors in RAW264. 7 cells / Biochimie 92:398~404
Balani, D. / 2013 / Interleukin-17A stimulates granulocyte-macrophage colony-stimulating factor release by murine osteoblasts in the presence of 1,25-dihydroxyvitamin D(3) and inhibits murine osteoclast development in vitro / Arthritis Rheum 65:436~446
Huang, W. / 2006 / Interleukin-17A : a T-cell-derived growth factor for murine and human mesenchymal stem cells / Stem Cells (Dayton, Ohio) 24:1512~1518
Huang, H. / 2009 / IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: implications for bone remodeling / Cell. Death. Differ 16:1332~1343
Nam, D. / 2012 / T-lymphocytes enable osteoblast maturation via IL-17F during the early phase of fracture repair / PloS One 7:e40044
Balani, D. / 2013 / Interleukin-17A stimulates granulocyte-macrophage colony-stimulating factor release by murine osteoblasts in the presence of 1,25-dihydroxyvitamin D(3) and inhibits murine osteoclast development in vitro / Arthritis Rheum 65:436~446
Huang, W. / 2006 / Interleukin-17A : a T-cell-derived growth factor for murine and human mesenchymal stem cells / Stem Cells (Dayton, Ohio) 24:1512~1518
Huang, H. / 2009 / IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: implications for bone remodeling / Cell. Death. Differ 16:1332~1343
Nam, D. / 2012 / T-lymphocytes enable osteoblast maturation via IL-17F during the early phase of fracture repair / PloS One 7:e40044
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