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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.9
- 수록면
- 227 - 236 (10page)
이용수
초록· 키워드
오류제보하기
The objective of this study was to evaluate the potential use of ginseng leaf as a cosmetic material. In this research, we employed enzymatic treated ginseng leaf by using Ultraflo L to improve the recovery of ginsenosides from the ginseng leaf and studied the biological activities and skin safety of the enzymatic treated ginseng leaf for use as a cosmetic material. The total ginsenoside contents of the non-enzymatic treated ginseng leaf (NEGL) and Ultraflo L treated ginseng leaf (UTGL) were 271 and 406 ㎎/g, respectively. The level of metabolite ginsenosides (sum of Rg2, Rg3, Rg5, Rk1, compound K, Rh1, Rh2, and F2) was higher in UTGL (93.1 ㎎) compared to NEGL (62.4 ㎎) in one gram ginseng leaf extract. The increase in amounts of ginsenoside types in UTGL compared to NEGL was generally 140% to 157%. UTGL exhibited relatively higher 2,2-diphenyl-2-picrylhydrazyl hydrate (IC??, 2.8 ㎎/mL) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (IC??, 1.6 ㎎/mL) radical scavenging activities compared to NEGL (4.8 ㎎/mL and 2.2 ㎎/mL). The UTGL group showed normalized hydrogen peroxide, lipid peroxidation and visual wrinkling grade induced-UVB exposure. The UTGL did not induce any adverse reactions such as erythema and edema on intact skin sites; however, some guinea pigs treated with UTGL on abraded skin sites showed very slight erythema. The primary irritation index (PII) score of UTGL was 0.05 and it was classified as a practically non-irritating material (PII, 0 to 0.5). In skin sensitization tests with guinea pigs, UTGL had a positive rate of skin sensitization at 40%, and the mean evaluation score was 0.4.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (39)
참고문헌 신청
1. [학술지(정기간행물)] - Zhang D / 1996 / Ginseng extract scavenges hydroxyl radical and protects unsaturated fatty acids from decomposition caused by iron-mediated lipid peroxidation / Free Radic Biol Med 20 : 145 ~ 150
2. [학술지(정기간행물)] - Chang LK / 2001 / The impact of herbal medicines on dermatologic surgery / Dermatol Surg 27 : 759 ~ 763
3. [학술지(정기간행물)] - 최성원 / 2002 / Epidermis Proliferative Effect of the Panax ginseng Ginsenoside Rb2 / Archives of Pharmacal Research 25 (1) : 71 ~ 76
4. [학술지(정기간행물)] - Keum YS / 2000 / Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng / Cancer Lett 150 : 41 ~ 48
5. [학술지(정기간행물)] - Kimura Y / 2006 / Effects of ginseng saponins isolated from Red Ginseng roots on burn wound healing in mice / Br J Pharmacol 148 : 860 ~ 870
2. [학술지(정기간행물)] - Chang LK / 2001 / The impact of herbal medicines on dermatologic surgery / Dermatol Surg 27 : 759 ~ 763
3. [학술지(정기간행물)] - 최성원 / 2002 / Epidermis Proliferative Effect of the Panax ginseng Ginsenoside Rb2 / Archives of Pharmacal Research 25 (1) : 71 ~ 76
4. [학술지(정기간행물)] - Keum YS / 2000 / Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng / Cancer Lett 150 : 41 ~ 48
5. [학술지(정기간행물)] - Kimura Y / 2006 / Effects of ginseng saponins isolated from Red Ginseng roots on burn wound healing in mice / Br J Pharmacol 148 : 860 ~ 870
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UCI(KEPA) : I410-ECN-0101-2012-524-003668379