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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.3
- 수록면
- 83 - 87 (5page)
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This test was performed to evaluate the skin irritation and sensitization of Creocide, disinfectant, containing 10% 4-chloro-m-cresol and 10% didecyl dimethyl ammonium chloride as main ingredients. In primary skin irritation test, rabbits were dermally treated with Creocide for 24 hrs. The disinfectant did not induce any adverse reactions such as erythema and edema on intact skin sites, but on abraded skin sites, some rabbits showed very slight erythema and edema 24 hr after topical application. So, the disinfectant was classified as a practically non-irritating material based on the score 0.29 of primary irritation index. In the skin sensitization test, guinea pigs were sensitized with intradermal injection of 0.1 ㎖ Freund's complete adjuvant emulsion (2-fold diluted), 0.1 ㎖ Creocide, and 0.1 ㎖ Creocide plus Freund's complete adjuvant emulsion (1 : 1) for 24 hrs. After 1 week, Creocide was treated on the site of injection, and challenged 2 weeks later. Creocide did not induce any allergic reactions. Therefore, Creocide was graded as a weak material from 0 in both sensitization score and rate. From results of the present study, it is suggested that Creocide does not cause contact irritation and sensitization.
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재료 및 방법
결과 및 고찰
참고문헌
참고문헌 (19)
참고문헌 신청
Andersen, A , 2006 , Final report on the safety assessment of sodium p-chloro-m-cresol, p-chloro-m-cresol, chlorothymol, mixed cresols, m-cresol, o-cresol, p-cresol, isopropyl cresols, thymo, o-cymen-5-ol, and carvacrol 25 : 29 ~ 127
Cronin , 1980 , Phenolic compounds. In Contact Dermatitis : 676 ~ 674
R.T.M , 1980 , Effects ofdisinfectants on pathogenic free-living amoebae : 33 1037 ~ 1041
M , 1986 , Repeated facialpalsies after chlorocresol inhalation. J. Neurol. Neurosurg. Psychiat.49 : 1452 ~ 1454
Environmental Protection Agency (EPA) , 2003 , Registration of the major change in label for the active ingredient didecyl dimethyl ammonium chloride contained in febreze antimicrobial (3573-69)
Cronin , 1980 , Phenolic compounds. In Contact Dermatitis : 676 ~ 674
R.T.M , 1980 , Effects ofdisinfectants on pathogenic free-living amoebae : 33 1037 ~ 1041
M , 1986 , Repeated facialpalsies after chlorocresol inhalation. J. Neurol. Neurosurg. Psychiat.49 : 1452 ~ 1454
Environmental Protection Agency (EPA) , 2003 , Registration of the major change in label for the active ingredient didecyl dimethyl ammonium chloride contained in febreze antimicrobial (3573-69)
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