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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.12
- 수록면
- 335 - 339 (5page)
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Fagopyritols are derivatives of D-chiro-inositol that accumulate in seeds of common buckwheat. This study investigates the effect of fagopyritol on glucose transport by cultured L6 muscle cells. The uptake of 2-deoxyglucose (2DG) by cultured L6 muscle cells is increased by the fagopyritol in a concentrationdependent manner with a maximum effect at 10?² M. Incubation of L6 muscle cells with D-pinitol (10?³ M) increased the basal uptake of 2DG by 3% after 10 min, by 38% after 4 hours, and by 41% after 24 hours. Whereas incubation of L6 muscle cells with fagopyritol (10?³ M) increased the basal uptake of 2DG by 15% after 10 min, by 61% after 4 hours, and by 450% after 24 hours. The effect of fagopyritol was inhibited by the phosphatidylinositol 3-kinase inhibitor (LY294,002). Fagopyritol induced the up-regulation of glucose transporter 4 in L6 cells. Taken together, fagopyritol may act via a post-receptor pathway of insulin action affecting glucose uptake.
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감사의 글
참고문헌
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - American Diabetes Association / 2008 / Economic costs of diabetes in the U.S. In 2007 / Diabetes Care 31 (3) : 596 ~ 615
2. [학술지(정기간행물)] - Bates, S.H. / 2000 / Insulin-like effect of pinitol / Br. J. Pharmacol 130 : 1944 ~ 1948
3. [학술지(정기간행물)] - Cho, E.J. / 2007 / Hypoglycemic effects of exopolysaccharides produced by mycelial cultures of two different mushrooms Tremella fuciformis and Phellinus baumii in ob/ob mice / Appl. Microbiol. Biotechnol 75 (6) : 1257 ~ 1265
4. [학술지(정기간행물)] - Fonseca, V.A / 2008 / Management of type 2 diabetes: oral agents, insulin, and injectables / J. Am. Diet. Assoc 108 (4) : S29 ~ S33
5. [학술지(정기간행물)] - Holman, G.D. / 1997 / From receptor to transporter: insulin signalling to glucose transport / Diabetologia 40 (9) : 991 ~ 1003
2. [학술지(정기간행물)] - Bates, S.H. / 2000 / Insulin-like effect of pinitol / Br. J. Pharmacol 130 : 1944 ~ 1948
3. [학술지(정기간행물)] - Cho, E.J. / 2007 / Hypoglycemic effects of exopolysaccharides produced by mycelial cultures of two different mushrooms Tremella fuciformis and Phellinus baumii in ob/ob mice / Appl. Microbiol. Biotechnol 75 (6) : 1257 ~ 1265
4. [학술지(정기간행물)] - Fonseca, V.A / 2008 / Management of type 2 diabetes: oral agents, insulin, and injectables / J. Am. Diet. Assoc 108 (4) : S29 ~ S33
5. [학술지(정기간행물)] - Holman, G.D. / 1997 / From receptor to transporter: insulin signalling to glucose transport / Diabetologia 40 (9) : 991 ~ 1003
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UCI(KEPA) : I410-ECN-0101-2010-510-001694255