지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.9
- 수록면
- 177 - 182 (6page)
이용수
초록· 키워드
오류제보하기
Macrophages play an important role in the first line of immunologic effects against tumor cells. The effects of nonsaponin red ginseng (NSRG) components on macrophage functions like tumoricidal activity, phagocytic activity, and NO production in young (8-weeks-old) and aged (82-weeks-old) male C57BL/6 mice were assessed in vitro, respectively. The treatment of tumor cells (melanoma B16 cells) with the supernatants of NSRG-treated macrophages resulted in an increase of cytotoxicity at 300 ㎍/㎖ in the aged mice, whereas the supernatants did not have a cytotoxic effect in the young mice. It was observed that the supernatants induced the increase of tumor cell proliferation at 150 ㎍/㎖ in the young mice, suggesting that the supernatants contain growth factors rather than cytotoxic molecules. In addition, NSRG alone had a direct cytotoxic effect on the B16 tumor cells. NSRG had no effect on the NO production by the macrophages in the young mice, while it significantly increased the level of NO release in the aged mice. There was no difference in the phagocytic activities of the macrophages by NSRG in both groups of mice. These results suggest that NSRG has differential effects on the macrophage functions in young and aged mice.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - 남기열 / 2005 / 홍삼과 백삼의 비교 고찰 / Journal of Ginseng Research 29 (1) : 1 ~ 18
2. [학술지(정기간행물)] - Okuda H / 1990 / Biological activities of non-saponin compounds isolated from Korea Red Ginseng / Korea J Ginseng Sci. 14 : 157 ~ 161
3. [학술지(정기간행물)] - Lee SD / 1990 / Inhibitory effect of crude acidic polysaccharide of Korean ginseng on lipolutic action of toxohormone-L from cancerous ascites fluid / Korea J Ginseng Sci. 14 : 10 ~ 13
4. [학술대회논문] - Okuda H / 1990 / Biological activities of non-saponin compounds isolated from Korean red ginseng / Proc. Int'l Ginseng Symp. on Korean Ginseng : 15 ~ 19
5. [학술대회논문] - Larina L / 1999 / Isolation of saponin-free fraction from ginseng (Panax ginseng C.A. Meyer) and its effects on the function of neutrophils. soluble non saponin constituents from Korean red ginseng (Panax ginseng C.A. Meyer): Immunomodulating activities of acidic polysaccharide / Proc of 99 Korea-Japan Ginseng Symp. : 191 ~
2. [학술지(정기간행물)] - Okuda H / 1990 / Biological activities of non-saponin compounds isolated from Korea Red Ginseng / Korea J Ginseng Sci. 14 : 157 ~ 161
3. [학술지(정기간행물)] - Lee SD / 1990 / Inhibitory effect of crude acidic polysaccharide of Korean ginseng on lipolutic action of toxohormone-L from cancerous ascites fluid / Korea J Ginseng Sci. 14 : 10 ~ 13
4. [학술대회논문] - Okuda H / 1990 / Biological activities of non-saponin compounds isolated from Korean red ginseng / Proc. Int'l Ginseng Symp. on Korean Ginseng : 15 ~ 19
5. [학술대회논문] - Larina L / 1999 / Isolation of saponin-free fraction from ginseng (Panax ginseng C.A. Meyer) and its effects on the function of neutrophils. soluble non saponin constituents from Korean red ginseng (Panax ginseng C.A. Meyer): Immunomodulating activities of acidic polysaccharide / Proc of 99 Korea-Japan Ginseng Symp. : 191 ~
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UCI(KEPA) : I410-ECN-0101-2009-524-018872482