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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.7
- 수록면
- 324 - 331 (8page)
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Channels formed by the co-assembly of the KCNQ1 subunit and the mink (KCNE1) subunit underline the slowly activating delayed rectifier K+ channels (I<SUB>Ks</SUB>) in the heart. This K+ channel is one of the main pharmacological targets for the development of drugs against cardiovascular disease. Panax ginseng has been shown to exhibit beneficial cardiovascular effects. In a previous study, we showed that ginsenoside Rg3 activates human KCNQ1 K+ channel currents through interactions with the K318 and V319 residues. However, little is known about the effects of ginsenoside metabolites on KCNQ1 K+ alone or the KCNQ1 + KCNE1 K+(I<SUB>Ks</SUB>) channels. In the present study, we examined the effect of protopanaxatriol (PPT) and compound K (CK) on KCNQ1 K+ and I<SUB>Ks</SUB> channel activity expressed in Xenopus oocytes. PPT more strongly inhibited the I<SUB>Ks</SUB> channel currents than the currents of KCNQ1 K+ alone in concentration- and voltage-dependent manners. The IC<SUB>50</SUB> values on IKs and KCNQ1 alone currents for PPT were 5.18±0.13 and 10.04±0.17 μM, respectively. PPT caused a leftward shift in the activation curve of I<SUB>Ks</SUB> channel activity, but minimally affected KCNQ1 alone. CK exhibited slight inhibition on I<SUB>Ks</SUB> and KCNQ1 alone K+ channel currents. These results indicate that ginsenoside metabolites show limited effects on I<SUB>Ks</SUB> channel activity, depending on the structure of the ginsenoside metabolites.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (35)
참고문헌 신청
1. [학술지(정기간행물)] - Wang Q / 1996 / Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias / Nat Genet 12 : 17 ~ 23
2. [학술지(정기간행물)] - Barhanin J / 1996 / K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current / Nature 384 : 78 ~ 80
3. [학술지(정기간행물)] - Sanguinetti MC / 1996 / Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel / Nature 384 : 80 ~ 83
4. [학술지(정기간행물)] - Pusch M / 1998 / Activation and inactivation of homomeric KvLQT1 potassium channels / Biophys J 75 : 785 ~ 792
5. [학술지(정기간행물)] - Seebohm G / 2001 / Identification of specific pore residues mediating KCNQ1 inactivation. A novel mechanism for long QT syndrome / J Biol Chem 276 : 13600 ~ 13605
2. [학술지(정기간행물)] - Barhanin J / 1996 / K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current / Nature 384 : 78 ~ 80
3. [학술지(정기간행물)] - Sanguinetti MC / 1996 / Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel / Nature 384 : 80 ~ 83
4. [학술지(정기간행물)] - Pusch M / 1998 / Activation and inactivation of homomeric KvLQT1 potassium channels / Biophys J 75 : 785 ~ 792
5. [학술지(정기간행물)] - Seebohm G / 2001 / Identification of specific pore residues mediating KCNQ1 inactivation. A novel mechanism for long QT syndrome / J Biol Chem 276 : 13600 ~ 13605
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UCI(KEPA) : I410-ECN-0101-2014-520-002962178