지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.7
- 수록면
- 203 - 207 (5page)
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초록· 키워드
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Background: There is limited understanding of the effect of dietary components on the absorption of ginsenosides and their metabolites into the blood.
Methods: This study investigated the pharmacokinetics of the ginseng extract and its main constituent ginsenoside Rb1 in rats with or without pretreatment with a prebiotic fiber, NUTRIOSE, by liquid chromatography tandem mass spectrometry. When ginsenoside Rb1 was incubated with rat feces, its main metabolite was ginsenoside Rd.
Results: When the intestinal microbiota of rat feces were cultured in vitro, their ginsenoside Rd-forming activities were significantly induced by NUTRIOSE. When ginsenoside Rb1 was orally administered to rats, the maximum plasma concentration (Cmax) and area under the plasma drug concentrationetime curve (AUC) for the main metabolite, ginsenoside Rd, were 72.4±31.6 ng/mL and 663.9 ±285.3 μg · h/mL, respectively. When the ginseng extract (2,000 mg/kg) was orally administered, Cmax and AUC for ginsenoside Rd were 906.5±330.2 ng/mL and 11,377.3± 4,470.2 μg · h/mL, respectively. When ginseng extract was orally administered to rats fed NUTRIOSE containing diets (2.5%, 5%, or 10%), Cmax and AUC were increased in the NUTRIOSE receiving groups in a dose-dependent manner.
Conclusion: These findings reveal that intestinal microflora promote metabolic conversion of ginsenoside Rb1 and ginseng extract to ginsenoside Rd and promote its absorption into the blood in rats. Its conversion may be induced by prebiotic diets such as NUTRIOSE.
Methods: This study investigated the pharmacokinetics of the ginseng extract and its main constituent ginsenoside Rb1 in rats with or without pretreatment with a prebiotic fiber, NUTRIOSE, by liquid chromatography tandem mass spectrometry. When ginsenoside Rb1 was incubated with rat feces, its main metabolite was ginsenoside Rd.
Results: When the intestinal microbiota of rat feces were cultured in vitro, their ginsenoside Rd-forming activities were significantly induced by NUTRIOSE. When ginsenoside Rb1 was orally administered to rats, the maximum plasma concentration (Cmax) and area under the plasma drug concentrationetime curve (AUC) for the main metabolite, ginsenoside Rd, were 72.4±31.6 ng/mL and 663.9 ±285.3 μg · h/mL, respectively. When the ginseng extract (2,000 mg/kg) was orally administered, Cmax and AUC for ginsenoside Rd were 906.5±330.2 ng/mL and 11,377.3± 4,470.2 μg · h/mL, respectively. When ginseng extract was orally administered to rats fed NUTRIOSE containing diets (2.5%, 5%, or 10%), Cmax and AUC were increased in the NUTRIOSE receiving groups in a dose-dependent manner.
Conclusion: These findings reveal that intestinal microflora promote metabolic conversion of ginsenoside Rb1 and ginseng extract to ginsenoside Rd and promote its absorption into the blood in rats. Its conversion may be induced by prebiotic diets such as NUTRIOSE.
목차
abstract
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (20)
참고문헌 신청
1. [학술지(정기간행물)] - Crow JM / 2011 / Microbiome: that healthy gut feeling / Nature 480 : 88 ~ 89
2. [학술지(정기간행물)] - 김동현 / 2012 / Chemical Diversity of Panax ginseng, Panax quinquifolium, and Panax notoginseng / Journal of Ginseng Research 36 (1) : 1 ~ 15
3. [학술지(정기간행물)] - Scheline RR / 1973 / Metabolism of foreign compounds by gastrointestinal microorganisms / Pharmacol Rev 25 : 451 ~ 523
4. [학술지(정기간행물)] - Mikov M / 1994 / The metabolism of drugs by the gut flora / Eur J Drug Metab Pharmacokinet 19 : 201 ~ 207
5. [학술지(정기간행물)] - Sousa T / 2008 / The gastrointestinal microbiota as a site for the biotransformation of drugs / Int J Pharm 363 : 1 ~ 25
2. [학술지(정기간행물)] - 김동현 / 2012 / Chemical Diversity of Panax ginseng, Panax quinquifolium, and Panax notoginseng / Journal of Ginseng Research 36 (1) : 1 ~ 15
3. [학술지(정기간행물)] - Scheline RR / 1973 / Metabolism of foreign compounds by gastrointestinal microorganisms / Pharmacol Rev 25 : 451 ~ 523
4. [학술지(정기간행물)] - Mikov M / 1994 / The metabolism of drugs by the gut flora / Eur J Drug Metab Pharmacokinet 19 : 201 ~ 207
5. [학술지(정기간행물)] - Sousa T / 2008 / The gastrointestinal microbiota as a site for the biotransformation of drugs / Int J Pharm 363 : 1 ~ 25
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