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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 565 - 573 (9page)
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초록· 키워드
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This study was performed to confirm the safety of the silk amino acids (SAA). Male and female Sprague-Dawley rats were orally administered with SAA at dose levels of 500, 1,000 or 2,000 ㎎/㎏ for 4 weeks. There was no significant difference in the body weight gain between vehicle control and SAA-treated rats. Also, significant changes in daily feed and water intakes were not observed. In hematological analysis, SAA decreased the rates of monocytes and eosinophils, while increasing that of lymphocytes, suggestive of reduced inflammatory response and immune potentiation. In particular, SAA significantly increased the numbers of red blood cells, showing microcytic erythropoiesis, and platelets, implying an enhanced hematopoiesis. In blood biochemistry, alanine transaminase, aspartate transaminase and lactate dehydrogenase were significantly reduced by SAA treatment, in contrast to the increases in glucose and albumin. Blood urea nitrogen and creatine phosphokinase also significantly decreased following SAA treatment. In spite of the decreases in the markers of liver, kidneys, skeletal and heart muscles, no remarkable lesions were observed in these organs. Such effects of SAA on the blood markers might be due to the stabilization or protective activities on the active organs, which may lead to enhanced resistance to hyperactivity, hypermotility or excitatory stress. Since no observed adverse-effect level of SAA was found to be higher than the upper-limit dose (2,000 ㎎/㎏), a 20-fold higher level of a clinicallyrecommended dose (100 ㎎/㎏), it is suggested that SAA possess a long-term safety, and that it could be a candidate for the improvement of hematopoiesis and stamina.
목차
재료 및 방법
결과 및 고찰
참고문헌
참고문헌 (16)
참고문헌 신청
1. [학술지(정기간행물)] - Akai, H / 1999 / New physiological functions of silk material / Shokuhin to kaihatsu 34 : 43 ~ 47
2. [학술지(정기간행물)] - Gotoh, K. / 2000 / Sulfate fibroin, a novel sulfated peptide derived from silk, inhibits human immunodeficiency virus replication in vitro / Biosci. Biotechnol. Bioche 64 : 1664 ~ 1670
3. [학술지(정기간행물)] - Hwang, E. / 2001 / Protein quality evaluation and effect of plasma contents of acid hydrolysates of cocoon in rats fed by high cholesterol, high triglyceride and high sucrose diet / J. Korean Soc. Food Sci.Nutr 30 : 1004 ~ 1009
4. [학술지(정기간행물)] - Tae Myoung Kim / 2008 / Effects of Red Ginseng Powder and Silk Peptide on Hypercholesterolemia and Atherosclerosis in Rabbits / Laboratory Animal Research 24 (1) : 67 ~ 75
5. [학술지(정기간행물)] - Lee, S.H. / 2002 / Physiology functional characteristic of silk peptide / Food Sci. Ind 35 : 57 ~ 62
2. [학술지(정기간행물)] - Gotoh, K. / 2000 / Sulfate fibroin, a novel sulfated peptide derived from silk, inhibits human immunodeficiency virus replication in vitro / Biosci. Biotechnol. Bioche 64 : 1664 ~ 1670
3. [학술지(정기간행물)] - Hwang, E. / 2001 / Protein quality evaluation and effect of plasma contents of acid hydrolysates of cocoon in rats fed by high cholesterol, high triglyceride and high sucrose diet / J. Korean Soc. Food Sci.Nutr 30 : 1004 ~ 1009
4. [학술지(정기간행물)] - Tae Myoung Kim / 2008 / Effects of Red Ginseng Powder and Silk Peptide on Hypercholesterolemia and Atherosclerosis in Rabbits / Laboratory Animal Research 24 (1) : 67 ~ 75
5. [학술지(정기간행물)] - Lee, S.H. / 2002 / Physiology functional characteristic of silk peptide / Food Sci. Ind 35 : 57 ~ 62
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UCI(KEPA) : I410-ECN-0101-2009-510-015707060