지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 1,045 - 1,048 (4page)
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The aim of our study was to evaluate the association between circulating levels of serum amyloid A protein (SAA) and disease activity in patients with juvenile idiopathic arthritis (JIA). Our study group included 41 JIA patients (9 male, 32 female),classified according to the International League of Associations for Rheumatology (ILAR) criteria (5); 16 had polyarticular onset disease and 25 had oligoarticular onset disease. Among 25 patients with oligoarticular disease, three had extended oligoarthritis. Serum amyloid A (SAA), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were measured in both patients and 26 healthy controls. SAA levels were higher in JIA patients versus healthy controls (p<0.001). Significant positive correlations were found between SAA and the presence of active joints (rho=0.363, p<0.05), the number of active joints (rho=0.418, p<0.05), ESR (R=0.702, p<0.05) and CRP (R=0.827, p<0.05). No significant correlations between ESR and the presence of active joints (rho=0.221, p=0.225) or between ESR and the number of active joints (rho=0.118, p=0.520) were demonstrated in JIA patients. No significant correlations were obtained between CRP and the presence of active joints (rho=0.034, p=0.855) or between CRP and the number of active joints (rho=0.033, p=0.859). We discovered a significant increase in SAA levels in JIA patients, compared to controls, and a strong positive correlation between SAA level and JIA disease activity. We also discerned SAA to be a more sensitive laboratory marker than ESR and CRP for evaluating the presence and number of active joints. We suggest that SAA can be used as an additional indicator of disease activity in JIA.
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참고문헌 (12)
참고문헌 신청
Cleary AG / 2000 / Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban, 1997 / J Rheumatol 27 : 1568 ~
Hachulla E / 1991 / Serum amyloid A concentrations in giant-cell arteritis and polymyalgia rheumatica: a useful test in the management of the disease / Clin Exp Rheumatol 9
Hagihara K / 2004 / IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed wi
Husby G / 1994 / Serum amyloid A (SAA): biochemistry, genetics and the pathogenesis of AA amyloidosis / Amyloid 1 : 119 ~ 137
Lange U / 2000 / Serum amyloid A--an indicator of inflammation in ankylosing spondylitis / Rheumatol Int 19 : 119 ~ 122
Hachulla E / 1991 / Serum amyloid A concentrations in giant-cell arteritis and polymyalgia rheumatica: a useful test in the management of the disease / Clin Exp Rheumatol 9
Hagihara K / 2004 / IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed wi
Husby G / 1994 / Serum amyloid A (SAA): biochemistry, genetics and the pathogenesis of AA amyloidosis / Amyloid 1 : 119 ~ 137
Lange U / 2000 / Serum amyloid A--an indicator of inflammation in ankylosing spondylitis / Rheumatol Int 19 : 119 ~ 122
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