지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 213 - 219 (7page)
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초록· 키워드
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This experiment was conducted to assess the changing patterns and relative values of acute phase proteins and inflammatory cytokines in experimental caprine coccidiosis. Eighteen newborn kids were allocated to 3 equal groups. Two groups, A and B, were inoculated with a single dose of 1×103 and1×105 sporulated oocysts of Eimeria arloingi, respectively. The third group, C, received distilled water as the control. Blood samples were collected from the jugular vein of each kid in both groups before inoculation and at days 7, 14, 21, 28, 35, and 42 post-inoculation (PI), and the levels of haptoglobin (Hp), serum amyloid A (SAA), TNF-α, and IFN-γ were measured. For histopathological examinations, 2 kids were selected from each group, euthanized, and necropsied on day 42 PI. Mean Hp concentrations in groups A and B (0.34 and 0.68 g/L) at day 7 PI were 3.2 and 6.3 times higher than the levels before inoculation. The mean SAA concentrations in groups A and B (25.6 and 83.5 μg/ml) at day 7 PI were 4.2 and 13.7 times higher than the levels before inoculation. The magnitude and duration of the Hp and SAA responses correlated well with the inoculation doses and the severity of the clinical signs and diarrhea in kids. These results were consistent with the histopathological features, which showed advanced widespread lesions in group B. In both groups, significant correlations were observed for TNF-α and IFN-γ with SAA and Hp, respectively. In conclusion, Hp and SAA can be useful non-specific diagnostic indicators in caprine coccidiosis.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (44)
참고문헌 신청
1. [학술지(정기간행물)] - van Miert AS / 1995 / Pro-inflammatory cytokines in a ruminant model: Pathophysiological, pharmacological, and therapeutic aspects / Vet Q 17 : 41 ~ 50
2. [학술지(정기간행물)] - Heinrich PC / 1990 / Interleukin-6 and the acute phase response / Biochem J 265 : 621 ~ 636
3. [학술지(정기간행물)] - Van Reeth K / 1998 / Bronchoalveolar interferon-alpha, tumor necrosis factor-alpha, interleukin-1, and inflammation during acute influenza in pigs: A possible model for humans / J Infect Dis 177 : 1076 ~ 1079
4. [학술지(정기간행물)] - Saini PK / 1991 / Application of acute phase reactants during antemortem and postmortem meat inspection / J Am Vet Med Assoc 198 : 1898 ~ 1901
5. [학술지(정기간행물)] - Suffredini AF / 1999 / New insights into the biology of the acute phase response / J Clin Immunol 19 : 203 ~ 214
2. [학술지(정기간행물)] - Heinrich PC / 1990 / Interleukin-6 and the acute phase response / Biochem J 265 : 621 ~ 636
3. [학술지(정기간행물)] - Van Reeth K / 1998 / Bronchoalveolar interferon-alpha, tumor necrosis factor-alpha, interleukin-1, and inflammation during acute influenza in pigs: A possible model for humans / J Infect Dis 177 : 1076 ~ 1079
4. [학술지(정기간행물)] - Saini PK / 1991 / Application of acute phase reactants during antemortem and postmortem meat inspection / J Am Vet Med Assoc 198 : 1898 ~ 1901
5. [학술지(정기간행물)] - Suffredini AF / 1999 / New insights into the biology of the acute phase response / J Clin Immunol 19 : 203 ~ 214
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UCI(KEPA) : I410-ECN-0101-2014-510-002511328