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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 460 - 469 (10page)
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초록· 키워드
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Heat shock proteins (HSPs) are induced as a self-defense mechanism of cells when exposed to various external stresses, such as high fever, infection, free radicals, and heavy metals. They affect the prognosis in the process of tumor formation. HSP is classified into four families: HSP27, HSP60, HSP90, and HSP100, depending on molecular weight. Heat shock protein 90 (HSP90), a molecular chaperone, plays an important role in the cellular protection against various stressful stimuli and in the regulation of cell cycle progression and apoptosis. In the present study, we assessed the differential expression of HSP90 family proteins in non-small cell lung cancer (NSCLC), and the correlation of their expression levels with clinicopathologic factors and patient survival rates. The result of this study can be summarized as follows; HSP90α showed higher expression in patients with no lymphovascular invasion (p=0.014). HSP90β showed a higher expression of squamous cell carcinoma (p=0.003), and an over expression of glucose-related protein (GRP94) was significantly associated with poor differentiation (p=0.048). However, none of the HSP90 proteins showed a significant association with the survival status in patients with NSCLC. This study also indicates that HSP90α might contribute more to the carcinogenesis of NSCLC than HSP90β, and GRP94 and isoform selectivity should be considered when HSP90 inhibitors are studied or utilized in the treatment of NSCLC.
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참고문헌 (27)
참고문헌 신청
Beck R / 2011 / Molecular chaperone Hsp90 as a target for oxidant-based anticancer therapies / Curr Med Chem 18 (18) : 2816 ~ 2825
Biaoxue R / 2012 / Upregulation of Hsp90-beta and annexin A1 correlates with poor s
Brandao GD / 2012 / The role of molecular pathology in non-small-cell lung carcinoma-now and in the future / Curr Oncol 19 (1) : 24 ~ 32
Bukau B / 1998 / The Hsp70 and Hsp60 chaperone machines / Cell 92 (3) : 351 ~ 366
Dobo C / 2013 / HSP27 is Commonly Expressed in Cervical Intraepithelial Lesions of Brazilian Women / Asian Pac J Cancer Prev 14 (9) : 5007 ~ 5010
Biaoxue R / 2012 / Upregulation of Hsp90-beta and annexin A1 correlates with poor s
Brandao GD / 2012 / The role of molecular pathology in non-small-cell lung carcinoma-now and in the future / Curr Oncol 19 (1) : 24 ~ 32
Bukau B / 1998 / The Hsp70 and Hsp60 chaperone machines / Cell 92 (3) : 351 ~ 366
Dobo C / 2013 / HSP27 is Commonly Expressed in Cervical Intraepithelial Lesions of Brazilian Women / Asian Pac J Cancer Prev 14 (9) : 5007 ~ 5010
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