지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.4
- 수록면
- 289 - 296 (8page)
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초록· 키워드
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Purpose: Inflammatory cells are known to be associated with the progression of atherosclerosis and plaque rupture. However, the relation to inflammatory cells and apolipoproteins on the progression of atherosclerosis is unknown. This study was aimed at examining the different expressions of inflammatory cells and evaluate the effect of apolipoprotein (APO) C1 and APO E during the progression of atherosclerosis. Methods: Ten atherosclerotic tissues were compared with five non-atherosclerotic tissues. The presence of vascular smooth muscle cells (VSMCs), macrophages, T-cells, APO C1, and APO E were identified by Western blotting and immunohistochemical analysis with antibodies. The senescence was analyzed by senescence-associated β-galactosidase. Results: The protein expression and senescence of macrophages, APO C1 and APO E were significantly higher in the main atherosclerotic lesion than the non-atherosclerotic lesion. A high concentration of inflammatory cells and the paucity of VSMCs were present in the shoulder area. In addition, macrophage and T-cells are expressed in the early stage of atherosclerotic development and more expanded in advanced atherosclerotic plaques. APO C1 was expressed mainly within the necrotic core, and APO E existed mostly around the necrotic core and the fibrous cap in advanced atherosclerotic plaques. Conclusion: Our study indicated that the expression and the senescence of macrophage and T-cells may be closelyrelated to induction and deposition of APO C1 and APO E. This contributes to the development and progression of atherosclerotic plaque by expanding the necrotic core.
목차
Purpose
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONFLICTS OF INTEREST
ACKNOWLEDGMENTS
REFERENCES
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Gordon D / 1990 / Cell proliferation in human coronary arteries / Proc Natl Acad Sci U S A 87 : 4600 ~ 4604
2. [학술지(정기간행물)] - O'Brien ER / 1993 / Proliferation in primary and restenotic coronary atherectomy tissue. Implications for antiproliferative therapy / Circ Res 73 : 223 ~ 231
3. [학술지(정기간행물)] - Katsuda S / 1993 / Human atherosclerosis. IV. Immunocytochemical analysis of cell activation and proliferation in lesions of young adults / Am J Pathol 142 : 1787 ~ 1793
4. [학술지(정기간행물)] - Kockx MM / 2000 / Apoptosis in atherosclerosis: beneficial or detrimental / Cardiovasc Res 45 : 736 ~ 746
5. [학술지(정기간행물)] - Leskinen MJ / 2003 / Regulation of smooth muscle cell growth, function and death in vitro by activated mast cells--a potential mechanism for the weakening and rupture of atherosclerotic plaques / Biochem Pharmacol 66 : 1493 ~ 1498
2. [학술지(정기간행물)] - O'Brien ER / 1993 / Proliferation in primary and restenotic coronary atherectomy tissue. Implications for antiproliferative therapy / Circ Res 73 : 223 ~ 231
3. [학술지(정기간행물)] - Katsuda S / 1993 / Human atherosclerosis. IV. Immunocytochemical analysis of cell activation and proliferation in lesions of young adults / Am J Pathol 142 : 1787 ~ 1793
4. [학술지(정기간행물)] - Kockx MM / 2000 / Apoptosis in atherosclerosis: beneficial or detrimental / Cardiovasc Res 45 : 736 ~ 746
5. [학술지(정기간행물)] - Leskinen MJ / 2003 / Regulation of smooth muscle cell growth, function and death in vitro by activated mast cells--a potential mechanism for the weakening and rupture of atherosclerotic plaques / Biochem Pharmacol 66 : 1493 ~ 1498
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UCI(KEPA) : I410-ECN-0101-2013-514-002684322