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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.12
- 수록면
- 349 - 354 (6page)
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The purpose of this study was to examine the effect of vanillic acid on the cell viability and melanogenesis in melanocytes damaged by reactive oxygen species (ROS). The human skin melanoma cells (SK-MEL-3) were cultured with various concentrations of hydrogen peroxide (H₂O₂). The cell viability for H₂O₂-induced cytotoxicity or vanillic acid against H₂O₂ was measured by XTT assay in these cultures. For the effect of vanillic acid on the melanogenesis, the tyrosinase inhibitory activity was measured by colorimetric assay at a wavelength of 490 ㎚, and melanin synthesis activity were assessed after cells were cultured in the media with or without various cencentrations of vanillic acid. In this study, H₂O₂ decreased cell viability dose- and time-dependent manners and XTT50 was determined at a concentration of 80 μM, H₂O₂. Vanillic acid increased the cell viability dose dependently in human skin melanoma cells damaged by H₂O₂-induced cytotoxicity. In the tyrosinase inhibitory activity, vanillic acid supresssed tyrosinase activity in dosedependent manner, and also decreased significantly melanin synthesis activity compared with H₂O₂-treated group. From these results. It is suggested that H₂O₂-mediated cytotoxicity was highly by the toxic criteria of Borenfreund and Puerner and also, vanillic acid has the protective effect on ROS-induced cytotoxicity and melanogenesis in these cultures.
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UCI(KEPA) : I410-ECN-0101-2010-510-001484668