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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국실험동물학회 Laboratory Animal Research THE KOREAN JOURNAL OF LABORATORY ANIMAL SCIENCE Vol.20 No.1
- 발행연도
- 2004.3
- 수록면
- 76 - 80 (5page)
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초록· 키워드
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To evaluate the induction of preneoplastic hepatic foci in relation to natural killer cell (NK) activity, we sequentially analyzed glutathione S-transferase placental form positive (GST-P?) hepatocytes and NK activity during diethylnitrosamine (DEN) and phenobarbital (PB)-induced hepatocarcinogenesis in Sprague-Dawley rats. Previous studies have shown that NK activity can modulate the carcinogenic process induced by chemical carcinogens. Newborn females were initially given a single intraperitoneal injection of 15㎎ DEN/㎏ and three weeks later, they were treated with 500ppm phenobarbital (PB). From week 3, PB was administered in drinking water for 9 weeks. Interim and terminal sacrifices were performed at weeks 1, 5 and 10. GST-P? hepatocytes increased with age in DEN-treated rats, especially in the population of more than 2 GST-P? hepatocytes. The NK activity of DEN-treated rats did not significantly differ from that of control rats until week 1, but it progressively decreased from week 5 to 10. These results indicate that changes of NK activity inversely correlated with the induction of preneoplastic hepatic foci. This strong correlation of decreased NK activity with enhanced induction of GST-P? foci suggests that NK activity is important in the early progression of hepatocarcinogenesis in rats.
목차
Introduction
Materials and Methods
Results
Discussion
References
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UCI(KEPA) : I410-ECN-0101-2009-510-016364463