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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.12
- 수록면
- 293 - 297 (5page)
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To know the role of NK cells during gastric carcinogenesis, especially in late stage of tumorigenesis, the changes of NK activity was examined. Rats were given N-methylnitrosourea (MNU) at a concentration of 100 ppm in their drinking water for 15 weeks. Rats were sacrificed sequentially on week 15, 20, 30, and 40 of experimental period. Histological changes such as mild erosion, regenerative changes, focal or severe atypical lesions and invasive adenocarcinoma were observed sequentially in the pyloric region. Adenomatous hyperplasia was induced in majority of the rat stomach in MNU treated group and incidence of adenocarcinoma was 20% in 40 weeks of MNU-treated group. There was no difference in NK activity until week 20, however, it was decreased in MNU-treated rats at week 30 and week 40, when compared to that of untreated control group. From week 15, the ratio of pepsinogen 1-altered pyloric gland (PAPG) between untreated control and MNU treated rats was progressively increased. These results suggest that PAPG is a relatively good marker for the evaluation in progression of gastric carcinogenesis and decreased NK activity is shown, esepcialy in late stage of gastric carcinogenesis.
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Materials and Methods
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UCI(KEPA) : I410-ECN-0101-2009-510-016362454