지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.12
- 수록면
- 278 - 282 (5page)
이용수
초록· 키워드
오류제보하기
The in-vitro immunomodulatory function of the activity of murine natural-killer (NK) cells induced by redginseng acidic polysaccharide (RGAP) was examined. RGAP induced the significant enhancement of NK cell activity against the Yac-1 tumor cells. The treatment of splenocytes cultured with RGAP for 16 h resulted in a significant increase in NK activity at the E:T ratio of 100:1, and in a 239 and 250% increase at 10 and l00 ㎍/㎖, respectively. We also demonstrate that RGAP treatment increased the production of interferon (IFN)-γ (17-125%) and tumor necrosis factor (TNF)-α (15-100%), suggesting that the increase in NK cell cytotoxicity could be due to the enhancement of the NK cell production of both cytokines. In addition, RGAP had a stimulating effect on lymphocyte proliferation in the presence of mitogens. Overall, these results suggest that RGAP has an immunopotentiating effect on NK cells, which can support the development of clinical studies on RGAP.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Djeu JY / 1983 / Production of interferon by natural killer cells / Clin Immunol Allergy 3 : 561 ~ 568
2. [단행본] - Herberman RB / 1985 / Mechanisms of cytotoxicity by NK cells / Academic Press
3. [학술지(정기간행물)] - Ross ME / 1997 / Cytokine-induced apoptosis of human natural killer cells identifies a novel mechanism to regulate the innate immune response / Blood 89 : 910 ~ 918
4. [학술지(정기간행물)] - Hersey P / 1980 / Tumor-related changes in natural killer activity in melanoma patients. Influence of stage of disease, tumor thickness and age of patients / Int J Cancer 25 : 187 ~ 194
5. [학술지(정기간행물)] - Wilmer LS / 1984 / Defects in natural cell activity and interferon response in human lung carcinoma and malignant melanoma / Cancer Res. 44 : 852 ~ 856
2. [단행본] - Herberman RB / 1985 / Mechanisms of cytotoxicity by NK cells / Academic Press
3. [학술지(정기간행물)] - Ross ME / 1997 / Cytokine-induced apoptosis of human natural killer cells identifies a novel mechanism to regulate the innate immune response / Blood 89 : 910 ~ 918
4. [학술지(정기간행물)] - Hersey P / 1980 / Tumor-related changes in natural killer activity in melanoma patients. Influence of stage of disease, tumor thickness and age of patients / Int J Cancer 25 : 187 ~ 194
5. [학술지(정기간행물)] - Wilmer LS / 1984 / Defects in natural cell activity and interferon response in human lung carcinoma and malignant melanoma / Cancer Res. 44 : 852 ~ 856
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Immunomodulation of NK Cell Activity by Red Ginseng Acidic Polysaccharide (RGAP) in Ovariectomized Rats
Journal of Ginseng Research
2009 .06
-
NK Cell-Based Immunotherapies in Cancer
Immune Network
2020 .04
-
홍삼 산성 다당체의 마크로파지 및 자연살해세포의 활성화에 의한 항암작용
약학회지
2002 .01
-
Optimization of Large-Scale Expansion and Cryopreservation of Human Natural Killer Cells for Anti-Tumor Therapy
Immune Network
2018 .08
-
Expansion and Activation of Natural Killer Cells for Cancer Immunotherapy
Annals of Laboratory Medicine
2009 .01
-
Inflammatory Mediators Modulate NK Cell-stimulating Activity of Dendritic Cells by Inducing Development of Polarized Effector Function
Immune Network
2007 .09
-
H2-M3의 세포 표면 발현이 NK 세포의 활성에 미치는 영향 분석
약학회지
2009 .01
-
A novel kit for the analysis of NK cell activity using whole blood : Measurement of NK cell activity in disease model mice
한국실험동물학회 학술발표대회 논문집
2017 .08
-
Signaling for Synergistic Activation of Natural Killer Cells
Immune Network
2012 .12
-
The Correlation between NK Cell and Liver Function in Patients with Primary Hepatocellular Carcinoma
Gut and Liver
2014 .01
-
홍삼산성다당체 (RGAP)의 경구투여에 의한 항종양 효과
Journal of Ginseng Research
2005 .12
-
Post-transcriptional Regulation of NK Cell Activation
Immune Network
2009 .08
-
홍삼산성다당체 (RGAP)와 항암제의 병용투여에 의한 항암시너지 효과
Journal of Ginseng Research
2003 .06
-
Cytotoxicity of natural killer cells co-cultured with γ-irradiatedor mitomycin C-treated feeder cells
예방수의학회지
2020 .01
-
Physical Inactivity and Unhealthy Metabolic Status Are Associated with Decreased Natural Killer Cell Activity
Yonsei Medical Journal
2018 .01
-
Engineering of Anti-CD133 Trispecific Molecule Capable of Inducing NK Expansion and Driving Antibody-Dependent Cell-Mediated Cytotoxicity
Cancer Research and Treatment
2017 .01
-
폐에 생긴 원발성 NK 세포 림프종 1예
대한내과학회지
2005 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2010-524-001705006