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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국실험동물학회 Laboratory Animal Research THE KOREAN JOURNAL OF LABORATORY ANIMAL SCIENCE Vol.20 No.1
- 발행연도
- 2004.3
- 수록면
- 44 - 48 (5page)
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초록· 키워드
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To provide basic information on blood for safety assessment, physiological levels of hematology and serum chemistry were ascertained in nineteen male (average body weight, 2.86 ㎏) and sixteen female (average body weight, 2.73 ㎏) cynomolgus monkeys. Hematologic parameters included fourteen items including red blood cells (RBC) hemoglobin (Hb), hematocrit (HCT), white blood cells (WBC) and differential leukocyte counts (%WBC). Serum biochemical parameters included twenty items including alkaline phosphatase (ALP), creatinine (CREA), creatine phosphokinase (CPK), triglyceride (TG), inorganic phosphorous (IP), etc. Hematological levels showed great variation in platelet, reticulocyte and WBC, whereas showed less variation in RBC, Hb, and HCT. Serum biochemical levels showed great variation in aspartate aminotransferase (AST), alanine aminotransferase (ALT), ALP, Blood urea nitrogen (BUN), glucose (GLU), total cholesterol (TCHO), CPK, TG, total bilirubin (TBIL), phospholipid (PL) and inorganic phosphate (IP), whereas showed less variation in albumin/globulin ratio (A/G ratio), total protein (TP), albumin (ALB), sodium (Na), potassium (K), chloride (Cl). Hematological determined showed greater values of Hb, and HCT in males than in females, while serum biochemical assay showed greater values of ALP, CPK and IP in males than in females. The present study will be valuable in the proper interpretation and validation of general toxicology studies using cynomolgus monkeys.
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