지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국실험동물학회 Laboratory Animal Research THE KOREAN JOURNAL OF LABORATORY ANIMAL SCIENCE Vol.20 No.4
- 발행연도
- 2004.12
- 수록면
- 333 - 347 (15page)
이용수
초록· 키워드
오류제보하기
Biodegradable materials have various important applications in the biomedical field. Before a biomaterial can be applied clinically, it has to be certified as to be noncytotoxic and biocompatible. Poly(D,L-lactic-co-glycolic acid) [PLGA] 65/35 scaffold, named InnoPol<SUP>ⓡ</SUP> manufactured by special gas foaming methods in Korea, has been subjected to assess on the physical-chemical characterization of scaffold and its extract. In addition, toxicity studies were performed to evaluate the InnoPol<SUP>ⓡ</SUP> as a medical device. Scanning electron microscopic (SEM) studies revealed that InnoPol<SUP>ⓡ</SUP> had relatively homologous pore structure possessing an average pore size of 73.98 urn and porosity of 89.69%. Differential scanning calorimetry thermograms showed that PLGA scaffold have a glass transition at 56.1℃. The toxicity studies showed that InnoPol<SUP>ⓡ</SUP> had no side effect such as cytotoxicity, hemolysis in vitro, genotoxicity, acute systemic toxicity, pyrogenicity, intracutaneous skin irritation reactivity, encapsulation in implantation and sensitization. These results suggest that PLGA scaffold, InnoPol<SUP>ⓡ</SUP> may have good mechanical properties with no side effect, and it would be useful in application as medical device for implantation.
목차
Introduction
Materials and Methods
Results
Discussion
Acknowledgment
References
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UCI(KEPA) : I410-ECN-0101-2009-510-016362141