지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 289 - 295 (7page)
이용수
초록· 키워드
오류제보하기
Toxicology screening following treatment with astemizole, a histamine receptor antagonist, at oral doses of 0, 10, 30 and 60 ㎎/㎏ was carried out in male cynomolgus monkeys (Macaca fascicularis). No dose-related changes in mortality, clinical signs, body weight changes, food consumption, or urine analysis occurred in any animal compared to the vehicle control. However, the high-dose group showed a decrease in BUN and ALP compared to vehicle control group. In addition, the levels of TG, AST, ALP and CK increased. Although astemizole did not produce significant toxicological changes at any dose tested, we predict that it can cause toxicological changes of the liver and heart based on the changes in the serum parameters related to the heart and liver. The Action Potential Duration (APD) was prolonged in the heart of 60 ㎎/㎏ treatment group compared to the control group. The APD increase in 60 ㎎/㎏ treatment group along the other related changes in toxicological parameters imply that astemizole has major cardiotoxic effects in the cynomolgus monkey. This study is a valuable assessment for predicting the general toxicity and cardiotoxic effects of antihistamine drugs using nonhuman primates.
목차
INTRODUCTION
MATERIALS AND METHOD
RESULT AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Gene Expression Changes in Peripheral Blood Mononuclear Cells from Cynomolgus Monkeys Following Astemizole Exposure
Molecular & cellular toxicology
2008 .01
-
Air Transport-induced Change in Hormone Level in Cynomolgus Monkeys
한국실험동물학회 학술발표대회 논문집
2005 .06
-
Cynomolgus Monkeys (Macacafascicularis) used in Toxicity Studies
한국실험동물학회 학술발표대회 논문집
2014 .02
-
Cynomolgus Monkey의 발란티디움 감염증 사례
Laboratory Animal Research
2003 .09
-
Incidental Case of Sarcocystis in Cynomolgus Monkey
한국수의병리학회 학술발표논문집
2005 .01
-
A Case of Bilateral Posterior Subcapsular Cataract in a Cynomolgus Monkey (Macaca fascicularis)
한국실험동물학회 학술발표대회 논문집
2017 .08
-
Reference values of hematology, serum biochemistry, and organ weights and locomotion for safety assessment using cynomolgus monkeys
한국실험동물학회 학술발표대회 논문집
2010 .08
-
Effective superovulation method according to weight and age of cynomolgus monkey (Macaca fascicularis)
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Reference range of clinical pathology parameters for cynomolgus monkeys (Macaca fascicularis) used in preclinical studies
한국실험동물학회 학술발표대회 논문집
2015 .02
-
게잡이 원숭이에 있어 새로운 헤파린유도체의 단회투여 독성스크리닝
Toxicological Research
2007 .06
-
Historical data of organ weights and gross lesions for cynomolgus monkeys (Macaca fascicularis ) used in preclinical studies
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Cynomolgus Monkey에 있어 혈액학 및 혈액생화학적 지표
Laboratory Animal Research
2004 .03
-
Reference values of hematological and serum biochemical parameters in young-adult cynomolgus monkey (Macaca fascicularis) and rhesus monkeys (Macaca mulatta) anesthetized with ketamine hydrochlorid
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Cynomolgus monkey(Macaca fascicularis)의 수입, 검역 및 사육관리의 실제
한국실험동물학회 학술발표대회 논문집
1998 .04
-
Rheumatoid arthritis modeling in cynomolgus monkeys
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Case Report of Balantidium coli in Cynomolgus Monkey
한국실험동물학회 학술발표대회 논문집
2003 .06
-
Incidental Case of Sarcocystis in Cynomolgus Monkey
Laboratory Animal Research
2005 .12
-
Preparation for transplantation in cynomolgus monkey for clinical trial in Korea
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Immunogenicity and safety profiles of anti-cancer vaccines in cynomolgus monkeys
한국실험동물학회 학술발표대회 논문집
2009 .08
이 논문의 저자 정보
최근 본 자료
댓글(0)
0