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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.12
- 수록면
- 339 - 342 (4page)
이용수
초록· 키워드
오류제보하기
The objective of the present study is to detect the potency of skin irritation of 3 types of β-glucan: Polycan, Tinocare GL and SC-glucan, after a subcutaneous injection at 2 g/㎏, respectively. Test articles were given single subcutaneous injection at the shaving back of rat one point per rat and they were sacrificed at 7 days after injection. Histopathological changes on the injection sites were observed with histomorphometry, the thickness of encapsulation and percentages of collagenous tissues in encapsulation regions. As results of subcutaneous injection of all three types of β-glucan, encapsulations consisted of inflammatory cells and connective tissues caused by skin irritation and foreign body reactions, were observed with microangiogenesis restricted to the injection sites. The most severe histopathological changes were detected in the SC-glucan and then in order of Tinocare GL and Polycan. Therefore, it is considered that the potency of the skin irritant caused by β-glucan is quite differed from their origin and they showed relatively lower irritation because the changes related to the irritation and foreign body reactions were restricted to the injection sites. Among three types of β-glucan tested in the present study, Polycan showed the lowest irritation and SC-glucan showed the highest skin irritation.
목차
Material and Methods
Results and Discussion
References
참고문헌 (11)
참고문헌 신청
1. [학술지(정기간행물)] - / 2005 / Rheological characterization of polysaccharide surfactant matricesfor cosmetic O W emulsions 290 : 546 ~ 556
2. [학술지(정기간행물)] - / 1999 / Efect of beta glucan from oats and yeaston serum lipids 39
3. [학술지(정기간행물)] - / / Structural and rheological characterization ofScleroglucan/borax hydrogel for drug delivery. Int. J. Biol.Macromol. 32 : 83 ~ 92
4. [학술지(정기간행물)] - / 1999 / Novel hydrogel system from scleroglucan synthesis and characterization 60 : 367 ~ 378
5. [학술지(정기간행물)] - / 1986 / The role of beta-glucan receptors on blood andtissue leukocytes in phagocytosis and metabolic activation.
2. [학술지(정기간행물)] - / 1999 / Efect of beta glucan from oats and yeaston serum lipids 39
3. [학술지(정기간행물)] - / / Structural and rheological characterization ofScleroglucan/borax hydrogel for drug delivery. Int. J. Biol.Macromol. 32 : 83 ~ 92
4. [학술지(정기간행물)] - / 1999 / Novel hydrogel system from scleroglucan synthesis and characterization 60 : 367 ~ 378
5. [학술지(정기간행물)] - / 1986 / The role of beta-glucan receptors on blood andtissue leukocytes in phagocytosis and metabolic activation.
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UCI(KEPA) : I410-ECN-0101-2009-510-016356156