지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.8
- 수록면
- 330 - 336 (7page)
- DOI
- 10.15188/kjopp.2015.08.29.4.330
이용수
초록· 키워드
오류제보하기
Polycan originating from Aureobasidium pullulans is mostly composed of β-1, 3/1, 6 glucans and possesses an anti-osteoporotic effect. We conducted a randomized, double-blind, placebo-controlled trial to examine the efficacy and safety of the polycan on bone biochemical markers in healthy perimenopausal women. Sixty subjects were randomly allocated to 2 groups?group 1 received 400 mg of polycan and group 2 received placebo?these were administered once daily for 28 days. Fasting blood and urine samples were collected at baseline and 4 weeks after treatment. The primary outcome was change in osteocalcin (OSC) and bone-specific alkaline phosphatase (BALP). Changes in calcium (Ca), phosphorus (P), C-telopeptide of collagen cross-links (CTx), N-telopeptide of collagen cross-links (NTx), and deoxypyridinoline (DPYR) were the secondary outcomes. A safety assessment was performed using adverse event (AE) and laboratory data. After 4 weeks of polycan treatment, OSC, DPYR, and BALP levels changed (P < 0.05) significantly from baseline in both groups. However, no significant differences were observed in any markers between the 2 groups, except for P (P < 0.05). Interestingly, group 2 showed a significant increase in CTx (65.2%, P < 0.05), while CTx in group 1 slightly increased (17.2%). Both groups showed no significant differences in AE. Although 4 weeks of polycan treatment did not have a statistically significant effect on bone metabolism biomarkers, increases in CTx were modestly inhibited by polycan. Further studies in a large population and longer treatment periods are needed to confirm the effect of polycan on bone turnover.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (25)
참고문헌 신청
[학술지(정기간행물)] - Hyeung-Sik Lee / 2005 / Single Oral Dose Toxicity Studies of Polycan, b-Glucan Originated from Aureobasidium in Mice / 한국독성학회지 21 (4) : 361 ~ 365
[학술지(정기간행물)] - 송희복 / 2006 / Effect of Exopolymers of Aureobasidium pullulans on Improving Osteoporosis Induced in Ovariectomized Mice / Journal of Microbiology and Biotechnology 16 (1) : 37 ~ 45
[학술지(정기간행물)] - Rahar, S. / 2011 / Preparation, characterization, and biological properties of beta-glucans / J Adv Pharm Technol Res 2 (2) : 94 ~ 103
[학술지(정기간행물)] - 최재석 / 2011 / In vitro Activities of Polycalcium, a Mixture of Polycan and Calcium Lactate- Gluconate, on Osteoclasts and Osteoblasts / 생명과학회지 21 (8) : 1199 ~ 1203
[학술지(정기간행물)] - Shin, H. D. / 2007 / Antiosteoporotic effect of Polycan, beta-glucan from Aureobasidium, in ovariectomized osteoporotic mice. / Nutrition 23 (11-12) : 853 ~ 860
[학술지(정기간행물)] - 송희복 / 2006 / Effect of Exopolymers of Aureobasidium pullulans on Improving Osteoporosis Induced in Ovariectomized Mice / Journal of Microbiology and Biotechnology 16 (1) : 37 ~ 45
[학술지(정기간행물)] - Rahar, S. / 2011 / Preparation, characterization, and biological properties of beta-glucans / J Adv Pharm Technol Res 2 (2) : 94 ~ 103
[학술지(정기간행물)] - 최재석 / 2011 / In vitro Activities of Polycalcium, a Mixture of Polycan and Calcium Lactate- Gluconate, on Osteoclasts and Osteoblasts / 생명과학회지 21 (8) : 1199 ~ 1203
[학술지(정기간행물)] - Shin, H. D. / 2007 / Antiosteoporotic effect of Polycan, beta-glucan from Aureobasidium, in ovariectomized osteoporotic mice. / Nutrition 23 (11-12) : 853 ~ 860
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