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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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We examined the effects of -glucan-reinforced PLGA film and scaffold on HDFs (human dermal fibroblast) attachment and proliferation. The PLGA films were prepared by simple solvent-casting method. The prepared films were grafted with (1→3)(1→6)--glucan in various ratios after plasma treatment on surface. The surface of the film was characterized by contact angle measurement, scanning electron microscope (SEM), and Fourier-transform infrared spectrophotometer (FT-IR). The amount of (1→3)(1→6)--glucan in the prepared film was indirectly determined by phenol-sulfuric acid method. The HDFs (Human dermal fibroblasts) were used to evaluate the cell attachment and proliferation on PLGA specimens before and after plasma/-glucan treatment. The result showed that the plasma treated groups exhibited more amount of -glucan might be grafted than the non plasma treated groups. Cell attachment was significantly enhanced in the plasma/-glucan grafted group after 4 hours incubation (p<0.05) due to the improved hydrophilicity and cytoactivity effect of the -glucan. The cell proliferation of plasma/-glucan (2mg/ml) grafted group was the highest rate among the groups (p<0.05).
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참고문헌 (15)
참고문헌 신청
/ 1998. / In vitro and in vivo release of ciprofloxacin from PLGA 50 54 : 167 ~ 175
/ 1998. / Prophylactic anti-infective activity of poly-[1-6]-beta-D-glucopyranosyl-[1-3]-beta-D-glucopyranose glucan in a guinea pig model of staphylococcal wound infection
/ 1998. / Synergism between poly- -beta-D- glucopyranosyl - [1-3]-beta-D-glucopyranose glucan and cefazolin in prophylaxis of staphylococcal wound infection 42 : 1 2449 ~ 6
/ 1999. / Surface hydrolysis of Poly mechs increase the seeding density of vascular smooth muscle cells 42 : 417 ~ 424
/ 2000. / Interaction of fibroblast cell onto physicochemically treated PLGA surfaces 24 : 869 ~ 876
/ 1998. / Prophylactic anti-infective activity of poly-[1-6]-beta-D-glucopyranosyl-[1-3]-beta-D-glucopyranose glucan in a guinea pig model of staphylococcal wound infection
/ 1998. / Synergism between poly- -beta-D- glucopyranosyl - [1-3]-beta-D-glucopyranose glucan and cefazolin in prophylaxis of staphylococcal wound infection 42 : 1 2449 ~ 6
/ 1999. / Surface hydrolysis of Poly mechs increase the seeding density of vascular smooth muscle cells 42 : 417 ~ 424
/ 2000. / Interaction of fibroblast cell onto physicochemically treated PLGA surfaces 24 : 869 ~ 876
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