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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.9
- 수록면
- 88 - 95 (8page)
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The present study was carried out to investigate the potential toxicity of dimethyl disulfide
by a 2-week inhalation in F344 rats. The test article, dimethyl disulfide, was exposed by inhalation
to male and female rats at dose levels of 0, 33, 100, or 300 ppm/6 hrs/day for 2 weeks. At the
end of treatment period, all males and females were sacrificed. During the test period, clinical signs,
mortality, body weights, food consumption, hematology, serum biochemistry, and gross findings were
examined. The mean body weights of the male 300 ppm group and the female 33 ppm or higher
dose groups were significantly lower than those of the control group, respectively. The mean food
consumption at male 300 ppm and female 100 and 300 ppm were significantly decreased compared
with the controls. Some treatment-related serum biochemical changes, including decreased alkaline
phosphatase at male 300 ppm and female 100 and 300 ppm, reduced total bilirubin at male 300
ppm, and decreased alanine aminotransferase at female 300 ppm, were observed in a dose-dependent
manner, but these findings were considered to be of no toxicological significance. There were no
adverse effects on mortality, clinical signs, hematology, and necropsy findings in any treatment group.
Based on these results, it was concluded that the 2-week repeated dose of dimethyl disulfide by inhalation
resulted in suppressed body weight gain and decreased food consumption at the dose of male
300 ppm and suppressed or reduced body weight gain and decreased food consumption at the dose
of female 33 ppm or higher. In the present experimental conditions, the no-observed-adverse-effect
level (NOAEL) was considered to be 100 ppm/6 hrs/day for male rats and below 33 ppm/6 hrs/day
for female rats.
by a 2-week inhalation in F344 rats. The test article, dimethyl disulfide, was exposed by inhalation
to male and female rats at dose levels of 0, 33, 100, or 300 ppm/6 hrs/day for 2 weeks. At the
end of treatment period, all males and females were sacrificed. During the test period, clinical signs,
mortality, body weights, food consumption, hematology, serum biochemistry, and gross findings were
examined. The mean body weights of the male 300 ppm group and the female 33 ppm or higher
dose groups were significantly lower than those of the control group, respectively. The mean food
consumption at male 300 ppm and female 100 and 300 ppm were significantly decreased compared
with the controls. Some treatment-related serum biochemical changes, including decreased alkaline
phosphatase at male 300 ppm and female 100 and 300 ppm, reduced total bilirubin at male 300
ppm, and decreased alanine aminotransferase at female 300 ppm, were observed in a dose-dependent
manner, but these findings were considered to be of no toxicological significance. There were no
adverse effects on mortality, clinical signs, hematology, and necropsy findings in any treatment group.
Based on these results, it was concluded that the 2-week repeated dose of dimethyl disulfide by inhalation
resulted in suppressed body weight gain and decreased food consumption at the dose of male
300 ppm and suppressed or reduced body weight gain and decreased food consumption at the dose
of female 33 ppm or higher. In the present experimental conditions, the no-observed-adverse-effect
level (NOAEL) was considered to be 100 ppm/6 hrs/day for male rats and below 33 ppm/6 hrs/day
for female rats.
목차
ABSTRACT
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