Single Oral Dose Toxicity Studies of PGB-2, a Novel Polyglucosamine Polymer Produced from Citrobacter sp. BL-4 in Mice

Yong-Hyun Lee; Mi-Kyung Son; Young-Mi Jung; Tae-Kwon Kim; Dong-Chan Park; Pan-Soo Kim; Sae-Kwang Ku

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자료유형: 학술저널

저자정보: Yong-Hyun Lee Mi-Kyung Son Young-Mi Jung Tae-Kwon Kim Dong-Chan Park Pan-Soo Kim Sae-Kwang Ku

저널정보: 한국독성학회 Toxicological Research Journal of Toxicology and Public Health Vol.23 No.1

발행연도: 2007.3

수록면: 65 - 72 (8page)

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This study was conducted to obtain information of the oral dose acute toxicity of PGB-2, a novel polyglucosamine polymer produced from Citrobacter sp. BL-4 (a new strain) in male and female mice. Mortality, body weight changes, clinical signs were monitored during 14 days after single oral dose of test article at dose levels of 2000, 1000, 500, 250 and 125 ㎖/㎏. Gross lesions, organ weight and histopathology of principal organs were examined after necropsy. As the results, we could not find any mortalities, clinical signs, changes in the body weight and gross findings except for white foci in the liver. In addition, no PGB-2-treatment related abnormal changes on the organ weight and histopathology of principle organs were detected except for atypical signs of liver. White liver foci were confirmed as focal infiltration of inflammatory cells. The results suggest that the PGB-2 is relatively safe in mice but the possibility of hepatotoxicity could not be excluded. The LD<SUB>50</SUB> and approximate LD in mice after single oral dose of PGB-2 were considered over 2000 ㎎/㎏, respectively. In future, the potential hepatotoxicity of PGB-2 should be evaluated through the repeat dose toxicity test prior to develop as a new agent.

#Polyglucosamine #PGB-2 #Polymer #Citrobacter #Single oral dose toxicity #Mice #Histopathology

참고문헌 (22)

참고문헌 신청

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