지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.4
- 수록면
- 186 - 194 (9page)
- DOI
- 10.15188/kjopp.2014.04.28.2.186
이용수
초록· 키워드
오류제보하기
The object of this study was to obtain acute toxicity information (single-dose oral toxicity) of Woohwangchungshim-won (WHCSW), a pill type herbal medicine used in Korean Medicine (KM) for treating stroke. In order to obtain the 50% lethal dose (LD50), approximate lethal dosage (ALD) and target organs, WHCSW powders were once orally administered to female and male ICR mice at dose levels of 2,000, 1,000, 500 and 0 (control) ㎎/㎏ (body weight.) according to the recommendation of Korea Food and Drug Administration (KFDA) Guidelines (Notification No. 2009-116). The mortality and changes in the body weight, clinical signs and gross observation were monitored for 14 days after single-dose oral administration of WHCSW according to KFDA Guidelines with organ weights and histopathological changes were observed in 12 principle organs. After single-dose oral administration of WHCSW, we could not find any mortality and toxicological evidences up to 2,000 ㎎/㎏-administered group, except for some accidental findings and dose-independent increases of body weight gains in female 1,000 and 500 ㎎/㎏ -administered female mice. The results obtained in this study suggest that the LD50 and ALD of WHCSW in both female and male mice after single-dose oral administration were considered as over 2,000 ㎎/㎏ because no mortalities were detected up to 2,000 ㎎/㎏ that was the highest dose recommended by KFDA and Organization for Economic Co-Operation and Development (OECD), and can be safely used in clinics.
목차
서론
재료 및 방법
고찰
결론
References
참고문헌 (30)
참고문헌 신청
1. [단행본] - Chen, S.W. / 1987 / Taiping hui min he ji ju fang / Xuan feng chu ban she : 81 ~
2. [단행본] - Heo, J. / 2007 / Donguibogam / Nam san dang : 362 ~
3. [학술지(정기간행물)] - Nam,, S.G. / 1990 / Experimental Studies on the Effects of Woowhangchungsimwon and Sohaphyangwon / J Kyung-Hee University Medical Center 6 (2) : 220 ~ 223
4. [학술지(정기간행물)] - 이제원 / 2010 / 우황청심원 관련 최근 연구 동향 : 국내 논문에 대한 고찰 / 대한한방내과학회지 31 (4) : 775 ~ 791
5. [학술지(정기간행물)] - 김형우 / 2007 / Microarray 분석법 활용을 통한 뇌출혈 흰쥐에서의 우황청심원 효능 평가 / 대한본초학회지 22 (4) : 253 ~ 260
2. [단행본] - Heo, J. / 2007 / Donguibogam / Nam san dang : 362 ~
3. [학술지(정기간행물)] - Nam,, S.G. / 1990 / Experimental Studies on the Effects of Woowhangchungsimwon and Sohaphyangwon / J Kyung-Hee University Medical Center 6 (2) : 220 ~ 223
4. [학술지(정기간행물)] - 이제원 / 2010 / 우황청심원 관련 최근 연구 동향 : 국내 논문에 대한 고찰 / 대한한방내과학회지 31 (4) : 775 ~ 791
5. [학술지(정기간행물)] - 김형우 / 2007 / Microarray 분석법 활용을 통한 뇌출혈 흰쥐에서의 우황청심원 효능 평가 / 대한본초학회지 22 (4) : 253 ~ 260
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-519-000932022