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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.9
- 수록면
- 201 - 208 (8page)
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초록· 키워드
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PI3-kinase activity through p85, the regulatory subunit of class IA PI3-kinase, is indispensable for the growth, differentiation, and survival of skeletal muscle cells, but little is known about the function of other regulatory subunits such as p55 and p50. We examined the subcellular localization and the expression of the regulatory subunits of class IA PI3-kinase in L6 myoblasts. Both p55 and p50 as well as p85 were expressed in L6 myoblasts. Whereas p85 was localized at both cytosolic and nuclear fractions, p55 and p50 were localized at only the nuclear fraction. During the differentiation of L6 myoblasts, the protein concentrations of both p55 and p50 were decreased but that of p85 was not significantly changed. Menadione-induced oxidative stress induced the translocation of p85 from cytosol to nucleus and the increase of p55 expression. These results suggest that the regulatory subunits of class IA PI3-kinase play an important role in L6 myoblasts.
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영어초록
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재료 및 방법
결과 및 고찰
REFERENCES
참고문헌 (31)
참고문헌 신청
[학술지(정기간행물)] - M,Asano / 1994 / Purification and characterization of nuclear phospholipase C specific for phosphoinositides. / J Biol Chem. 269
[학술지(정기간행물)] - B,Ateghang / 2006 / Regulation of cardiotrophin-1 expression in mouse embryonic stem cells by HIF-1{alpha} and intracellular reactive oxygen species / J Cell Sci. 119 : 1043 ~ 1052
[학술지(정기간행물)] - D,Bacqueville / 2001 / Characterization of a G protein-activated phosphoinositide 3-kinase in vascular smooth muscle cell nuclei / J Biol Chem. 276
[학술지(정기간행물)] - J,Berger / 1994 / PI 3-kinase activation is required for insulin stimulation of glucose transport into L6 myotubes / Biochem Biophys Res Commun. 205 : 570 ~ 576
[학술지(정기간행물)] - R,Bischoff / 1969 / Mitosis and the process of differentiation of myogenic cells in vitro / J Cell Biol. 41 : 188 ~ 200
[학술지(정기간행물)] - B,Ateghang / 2006 / Regulation of cardiotrophin-1 expression in mouse embryonic stem cells by HIF-1{alpha} and intracellular reactive oxygen species / J Cell Sci. 119 : 1043 ~ 1052
[학술지(정기간행물)] - D,Bacqueville / 2001 / Characterization of a G protein-activated phosphoinositide 3-kinase in vascular smooth muscle cell nuclei / J Biol Chem. 276
[학술지(정기간행물)] - J,Berger / 1994 / PI 3-kinase activation is required for insulin stimulation of glucose transport into L6 myotubes / Biochem Biophys Res Commun. 205 : 570 ~ 576
[학술지(정기간행물)] - R,Bischoff / 1969 / Mitosis and the process of differentiation of myogenic cells in vitro / J Cell Biol. 41 : 188 ~ 200
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UCI(KEPA) : I410-ECN-0101-2009-510-017357308