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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 73 - 76 (4page)
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Protein phosphatase 2A (PP2A) is a serine and threonine protein phosphatase that regulates cell cycle progression and apoptosis. PP2A is composed of various subunits. Among these subunits, subunit B plays an important role in the modulation of PP2A function in the brain. This study investigated PP2A subunit B expression levels after neuronal cell injury. Middle cerebral artery occlusions (MCAO) were surgically induced in adult male rats to induce focal cerebral ischemic injury, and brain tissues were collected 24 h after MCAO. A proteomic approach revealed reduction of PP2A subunit B protein spots in MCAOoperated animals in comparison to sham-operated animals. Western blot analysis confirmed that MCAO induces reductions in PP2A subunit B levels. Moreover, glutamate exposure induces neuronal cell death and leads to reductions of PP2A subunit B levels in a hippocampal-derived cell line. This study demonstrated the decrease of PP2A subunit B in ischemic neuronal cell injury. These results suggest that the decrease of PP2A subunit B after ischemic brain injury can mediate neuronal cell death.
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참고문헌 (16)
참고문헌 신청
Ferrer I / 2003 / Signaling of cell death and cell survival following focal cerebral ischemia: life and death struggle in the penumbra / J Neuropathol Exp Neurol 62(4):329~339
Gong CK / 2000 / Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer’ disease / J Biol Chem 275(8):5535~5544
Janssens V / 2001 / Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling / Biochem J 353(3):417~439
Koh PO / 2007 / 17Beta-estradiol prevents the glutamate-induced decrease of Akt and its downstream targets in HT22 cells / J Vet Med Sci 69(3):285~288
Koh PO / 2010 / Proteomic Analysis of Focal Cerebral Ischemic Injury in Male Rats / JOURNAL OF VETERINARY MEDICAL SCIENCE 72(0):181~185
Gong CK / 2000 / Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer’ disease / J Biol Chem 275(8):5535~5544
Janssens V / 2001 / Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling / Biochem J 353(3):417~439
Koh PO / 2007 / 17Beta-estradiol prevents the glutamate-induced decrease of Akt and its downstream targets in HT22 cells / J Vet Med Sci 69(3):285~288
Koh PO / 2010 / Proteomic Analysis of Focal Cerebral Ischemic Injury in Male Rats / JOURNAL OF VETERINARY MEDICAL SCIENCE 72(0):181~185
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UCI(KEPA) : I410-ECN-0101-2012-510-004225576