지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.9
- 수록면
- 153 - 160 (8page)
이용수
초록· 키워드
오류제보하기
Human colon cancer is the second most fatal disease among a variety of cancers to cause cancer death in U.S.A. and its incidence rate is currently increased in Korea. Recently, many studies have been being progressed on the efficacy of diverse combination treatments. But results of these studies in vitro were not similar those in vivo. This study compared the anticancer reactions between each use of arsenic trioxide and taxol against human colon cancer HT-29 cell line and combined use of two drugs. And these results compared with the results of HT-29 spheroid cells having similar characteristics to the solid tumor in vivo. The spheroid of HT-29 cells was formed by using a multicellular spheroid system and the result was observed through electron microscopy. In vitro cytotoxicity of each use of arsenic trioxide and taxol was evaluated in HT-29 monolayer cells. The IC<SUB>50</SUB> value for arsenic trioxide was to be 33 μM and taxol was to be 18 nM. The result treated with the combination of taxol and arsenic trioxide decreased the cytotoxicity on the HT-29 monolayer cells. The spheroid cells represented higher resistance against drugs than the monolayer cells. I demonstrated DNA fragmentation after incubation with concentrations more than 10 μM arsenic trioxide and 100 nM taxol for 48 h on the monolayer cells. But the results of HT-29 cell line treated with the combination of taxol and arsenic trioxide was the same as the outcome of control samples that were not treated with any drug. And I don't demonstrated DNA fragmentation on the spheroid cells. These results suggest that apoptosis was not induced in the use of the combination can be thought as that arsenic trioxide might work as an antagonist to inhibit a taxol mechanism to induce apoptosis. And the spheroid cells represented higher resistance against drugs than the monolayer cells.
목차
영어초록
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (28)
참고문헌 신청
[학술지(정기간행물)] - K,Bhalla / 1993 / Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells / Leukemia 7 : 563 ~ 568
[학술지(정기간행물)] - G,Carles / 1998 / The effect of combining antitubulin agents on differentiated and undifferentiated human colon cancer cells / Anticancer Drugs 9 : 209 ~ 221
[학술지(정기간행물)] - C,Chiung-Tong / 1997 / Differential time dependency of antiproliferative and apoptotic effects of taxol in human prostate tumors / Urol Oncol. 3 : 11 ~ 17
[학술지(정기간행물)] - WB,Derry / 1995 / Wilson L, Jordan MA suppresses microtubule dynamics / Biochemistry 34 : 2203 ~ 2211
[학술지(정기간행물)] - B,Desoize / 2000 / Multicellular resistance: a paradigm for clinical resistance? / Crit Rev Oncol Hematol. 36 : 193 ~ 207
[학술지(정기간행물)] - G,Carles / 1998 / The effect of combining antitubulin agents on differentiated and undifferentiated human colon cancer cells / Anticancer Drugs 9 : 209 ~ 221
[학술지(정기간행물)] - C,Chiung-Tong / 1997 / Differential time dependency of antiproliferative and apoptotic effects of taxol in human prostate tumors / Urol Oncol. 3 : 11 ~ 17
[학술지(정기간행물)] - WB,Derry / 1995 / Wilson L, Jordan MA suppresses microtubule dynamics / Biochemistry 34 : 2203 ~ 2211
[학술지(정기간행물)] - B,Desoize / 2000 / Multicellular resistance: a paradigm for clinical resistance? / Crit Rev Oncol Hematol. 36 : 193 ~ 207
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Combined Treatment with Coptidis Rhizoma Extract and Arsenic Trioxide Enhanced Apoptosis through Diverse Pathways in H157 Cells
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Apoptosis of Hepatocytes in Rats Treated with Taxol
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Arsenic Trioxide Induces Apoptosis in Human Colorectal Adenocarcinoma HT-29 Cells Through ROS
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Fungal Taxol Extracted from Cladosporium oxysporum Induces Apoptosis in T47D Human Breast Cancer Cell Line
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자궁육종 세포주에서 Taxol의 효과
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Mineral Trioxide Aggregate의 임상 적용
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Inhibition of Nemo-like Kinase Increases Taxol Sensitivity in Laryngeal Cancer
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Taxol의 방사면역측정을 위한 I-125 표지화합물 합성
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UCI(KEPA) : I410-ECN-0101-2009-510-017357237