지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.9
- 수록면
- 193 - 197 (5page)
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초록· 키워드
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The aim of this work was to study the anti-tumor effect by combined treatment of arsenic trioxide and interferon-α (IFN-α) in mice injected murine Lewis lung carcinoma (LL2) cells. As a experimental model, LL2 cells (1×10?/mouse) were injected subcutaneously into the back region of mice. When the tumor volume reached about 100 ㎣, mice were treated with 1 ㎎/㎏ arsenic trioxide, 50,000 IU IFN-α, or arsenic trioxide plus IFN-α, respectively. The development of tumor cells was significantly inhibited by combined treatment with arsenic trioxide and IFN-α. In arsenic trioxide and IFN-α treated group, the expression of proliferating cell nuclear antigen (PCNA) was reached a peak level at 0 hr and it was decreased from 12 hr to 48 hr after the treatment. PCNA is known to be associated with S phase and DNA replication of the cell cycle. Whereas, apoptotic index was reached a peak level at 48 hr after the treatment and it was nearly restored to the control level at 8 days. In conclusion, our results suggest that the combined treatment with arsenic trioxide and IFN-α inhibited the growth of LL2 tumor cells through the suppression of cell proliferation and the induction of apoptosis.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
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UCI(KEPA) : I410-ECN-0101-2009-510-016362292