지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Inflammation appears to have a major role in the development of atherosclerosis. Cyclooxygenase-2 (COX-2) is involved in the inflammatory response via the generation of prostanoids that, in turn, are involved in the production of matrix metalloproteinases (MMPs). This study hypothesized that a vascular infection with cytomegalovirus (CMV) may induce a chronic inflammatory reaction and activated inflammatory cells may express inflammatory mediators such as cyclooxygenase-2 (COX-2) and matrix metalloproteinases-9 (MMP-9). To confirm the hypothesis, the immunohistochemical stains for CMV late antigen, COX-2, MMP-9, macrophage, and T-lymphocyte were performed on CMV-infected atherosclerotic lesions. The immunoreactivity for COX-2 and MMP-9 was evident in all cases of atherosclerosis along with plaques, mainly in macrophages/foamy cells, intimal and medial smooth muscle cells, and endothelial cells of the intima. Within the intima, the increased immunoreactivity for COX-2 and MMP-9 was colocalized to the area stained with CMV late antigen. Sections from control specimens showed no immunoreactivity for CMV late antigen, COX-2 and MMP-9. These data seem to support the hypothesis that CMV may participate in a pathogenetic mechanism for atherogenesis or progression of atherosclerosis.
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영어 초록
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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Detection of Cytomegalovirus in Atherosclerotic Aorta and Coronary Artery by In Situ Hybridization and PCR
대한의생명과학회지
2002 .12
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Adoptive Immunotherapy for Cytomegalovirus (CMV) Disease in Immunocompromised Patients
Yonsei Medical Journal
2004 .01
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비강 및 부비동 종양에서 Cyclooxygenase-2 및 Matrix Metalloproteinases의 발현
대한이비인후-두경부외과학회지
2004 .01
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Prognostication by Cluster Analysis of COX-2, MMP-9 and P53 Expression and by Clinico-pathologic Correlation Analysis in Non-small Cell Lung Cancer
Tuberculosis and Respiratory Diseases
2007 .01
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Diagnostic Usefulness of Cytomegalovirus (CMV)- Specific T Cell Immunity in Predicting CMV Infection after Kidney Transplantation: A Pilot Proof-of- Concept Study
Infection and Chemotherapy
2015 .01
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Immunological Prediction of Cytomegalovirus (CMV) Replication Risk in Solid Organ Transplantation Recipients: Approaches for Regulating the Targeted Anti-CMV Prevention Strategies
Infection and Chemotherapy
2017 .01
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Upregulation of MMP is Mediated by MEK1 Activation During Differentiation of Monocyte into Macrophage
대한의생명과학회지
2012 .06
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Comparison of the Commercial QuantiFERON-CMV and Overlapping Peptide-based ELISPOT Assays for Predicting CMV Infection in Kidney Transplant Recipients
Immune Network
2017 .10
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Characterization of Matrix Metalloproteinase Expression in Triglyceride Treated THP-1 Macrophages
대한의생명과학회지
2013 .03
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Up-Regulation of Cyclooxygenase 2 and Matrix Metalloproteinases-2 and -9 in Cutaneous Squamous Cell Carcinoma: Active Role of Inflammation and Tissue Remodeling in Carcinogenesis
Annals of Dermatology
2013 .01
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간이식 환자에서 CMV 항원혈증 검사의 임상적 유용성에 대한 고찰
Infection and Chemotherapy
2005 .01
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The Detailed Kinetics of Cytomegalovirus-specific T cell Responses after Hematopoietic Stem Cell Transplantation : 1 Year Follow-up Data
Immune Network
2018 .04
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Correlation of expression and activity of matrix metalloproteinase-9 and -2 in human gingival cells of periodontitis patients
Journal of Periodontal & Implant Science
2013 .01
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유방암종의 MMP-2와 MMP-9 발현과 예후 인자와의 연관성
Journal of Pathology and Translational Medicine
2004 .01
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Matrix Metallopeptidases (MMPs) Polymorphisms with Obese Patients in Korean Population
스트레스硏究
2009 .06
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Associations between Single Nucleotide Polymorphisms of COX-2 and MMP-2 Genes and Colorectal Cancer Susceptibility in the Saudi Population
Asian Pacific journal of cancer prevention : APJCP
2014 .01
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Annals of Clinical Microbiology
2006 .01
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Serum Level of Matrix Metalloproteinase-2 and -9 in Patients with Laryngeal Squamous Cell Carcinoma and Clinical Significance
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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Serum Levels of MMP9 and MMP2 in Patients with Oral Squamous Cell Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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Early and Late Changes of MMP-2 and MMP-9 in Bleomycin-Induced Pulmonary Fibrosis
Yonsei Medical Journal
2009 .01
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UCI(KEPA) : I410-ECN-0101-2009-510-017341060