지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 20 - 26 (7page)
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초록· 키워드
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Objectives: The study aimed to determine changes in laboratory data for cancer patients receiving Korean medicine (KM) care, with a focus on patients’ functional status, cancer-coagulation factors and cancer immunity.
Methods: We conducted an observational study of various cancer patients in all stages admitted to the East-West Cancer Center (EWCC), Dunsan Korean Hospital of Daejeon University, from Mar. 2011 to Aug. 2011. All patients were under the center’s multi-modality Korean-medicine-based inpatient cancer care program. The hospitalization stay at EWCC ranged from 9 to 34 days. A total of 80 patients were followed in their routine hematologic laboratory screenings performed before and after hospitalization. Patients were divided into three groups depending on the status of their treatment: prevention of recurrence and metastasis group, KM treatment only group, and combination of conventional and KM treatment group. The lab reports included natural killer cell count (CD16 + CD56), fibrinogen, white blood cell (WBC), lymphocytes, monocytes, neutrophil, red blood cell (RBC), hemoglobin, platelet, Erythrocyte Sedimentation Rate (ESR), and Eastern Cooperative Oncology Group (ECOG) performance status.
Results: With a Focus on patients’ functional status, cancer-coagulation factors and cancer immunity, emphasis was placed on the NK cell count, fibrinogen count, and ECOG scores. Data generally revealed decreased fibrinogen count, fluctuating NK cell count and decreased ECOG, meaning improved performance status in all groups. The KM treatment only group showed the largest decrease in mean fibrinogen count and the largest increase in mean NK cell count. However, the group’s ECOG score showed the smallest decrease, which may be due to the concentration of late-cancer-stage patients in that particular group.
Conclusions: Multi-modality KM inpatient care may have positive effect on lowering the cancer coagulation factor fibrinogen, but its correlation with the change in the NK cell count is not clear.
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참고문헌 (36)
참고문헌 신청
Konjevic G. / 2011 / Association of decreased NK cell activity and IFNγ expression with pSTAT dysregulation in breast cancer patients / J BUON 16(2):219~226
Boccaccio C. / 2005 / The MET oncogene drives a genetic programme linking cancer to haemostasis / Nature 434(7031):396~400
Rong Y. / 2005 / PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma / Cancer Res 65(4):1406~1413
Yu JL. / 2005 / Oncogenic events regulate tissue factor expression in colorectal cancer cells : implications for tumor progression and angiogenesis / Blood 105(4):1734~1741
Abe K. / 1999 / Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor / Proc Natl Acad Sci U S A 96(15):8663~8668
Boccaccio C. / 2005 / The MET oncogene drives a genetic programme linking cancer to haemostasis / Nature 434(7031):396~400
Rong Y. / 2005 / PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma / Cancer Res 65(4):1406~1413
Yu JL. / 2005 / Oncogenic events regulate tissue factor expression in colorectal cancer cells : implications for tumor progression and angiogenesis / Blood 105(4):1734~1741
Abe K. / 1999 / Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor / Proc Natl Acad Sci U S A 96(15):8663~8668
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