지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.8
- 수록면
- 116 - 122 (7page)
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초록· 키워드
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This study was conducted to determine whether CD4 T cell responses to citrullinated fibrinogen occur in patients with rheumatoid arthritis (RA), especially in HLA-DR4-positive subjects. Whole peripheral blood mononuclear cells (PBMCs) of RA patients and control subjects were stimulated with citrullinated fibrinogen peptides, and T-cell production of proliferation and proinflammatory cytokines, such as interferon-γ(IFN-γ) and interleukin-17A (IL-17A), were measured. In addition, CD4 T cells from RA patients were stimulated with the citrullinated fibrinogen peptide, Fib-α R84Cit, identified as a DRB1*0401-restricted T cell epitope in HLA-DR4 transgenic mice, and the degree of T cell activation was examined similarly. No proliferative responses to the citrullinated fibrinogen peptides were observed in whole PBMCs or CD4 T cells from RA patients. Furthermore, no increased production of IFN-γor IL-17A was found in whole PBMCs or CD4 T cells stimulated with the citrullinated fibrinogen peptides, although these cells responded to recall antigen, a mixture of tetanus toxoid, purified protein derivative (PPD) from Mycobacterium tuberculosis, and Candida albicans. The results of this study indicate that anti-citrulline immunity in RA patients may be mediated by fibrinogen because there is no evidence of CD4 T cell-mediated immune responses to citrullinated fibrinogen peptides.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (16)
참고문헌 신청
1. [학술지(정기간행물)] - Klareskog, L. / 2009 / Rheumatoid arthritis / Lancet 373 : 659 ~ 672
2. [학술지(정기간행물)] - Imboden, J. B. / 2009 / The immunopathogenesis of rheumatoid arthritis / Annu. Rev. Pathol 4 : 417 ~ 434
3. [학술지(정기간행물)] - Klareskog, L. / 2008 / Immunity to citrullinated proteins in rheumatoid arthritis / Annu. Rev. Immunol 26 : 651 ~ 675
4. [학술지(정기간행물)] - Kuhn, K. A. / 2006 / Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis / J. Clin. Invest 116 : 961 ~ 973
5. [학술지(정기간행물)] - van der Helm-van Mil, A. H. / 2006 / The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis / Arthritis. Rheum 54 : 1117 ~ 1121
2. [학술지(정기간행물)] - Imboden, J. B. / 2009 / The immunopathogenesis of rheumatoid arthritis / Annu. Rev. Pathol 4 : 417 ~ 434
3. [학술지(정기간행물)] - Klareskog, L. / 2008 / Immunity to citrullinated proteins in rheumatoid arthritis / Annu. Rev. Immunol 26 : 651 ~ 675
4. [학술지(정기간행물)] - Kuhn, K. A. / 2006 / Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis / J. Clin. Invest 116 : 961 ~ 973
5. [학술지(정기간행물)] - van der Helm-van Mil, A. H. / 2006 / The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis / Arthritis. Rheum 54 : 1117 ~ 1121
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UCI(KEPA) : I410-ECN-0101-2016-511-001746068