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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.3 No.2
발행연도
1998.6
수록면
193 - 197 (5page)

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This study was conducted to determine if dietary fiber would reduce exposure of the tissues to dietary benzo[a]pyrene (BP), a well-known carcinogenic polycyclic aromatic hydrocarbon, as evaluated by benzo[a]pyrene hydroxylase (BPH) activity. The effects of three different sources of dietary fiber (pectin, poly-dextrose, and cellulose) on BPH activity were studied using Sprague-Dawley rats. In this study, male rats were fed a fiber-free purified diet for 7days, whereupon they were switched to experimental diets for 48h. After 48h, their liver, stomach, small intestinal mucosa and large intestinal mucosa were assayed for BPH activity. Tissues exposed to benzo[a]pyrene (400 ㎎/㎏ diet, fiber-free) showed significant increase in the activity of BPH; 27 times in liver, 7 times in stomach, 18 times in small intestinal mucosa and 3 times in large intestine. The inhibition in BP-induced BPH activity by dietary fiber in liver, stomach and small intestinal mucosa was observed in the decreasing order: 10% pectin> 10% polydextrose> 5% polydextrose> 10% cellulose. Decreased BPH induction indicates that soluble dietary fibers, especially pectin and poly-dextrose in this study, protect the tissues of digestive system from exposure to BP.

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Abstract

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

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