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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.9
- 수록면
- 132 - 135 (4page)
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초록· 키워드
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This study was perfonned to investigate the anxiolytic etl'ects of total sponin fraction from Ginseng Radix Rubra (KRG) in mice using the elevated plus-maze model. The water extract of KRG and ginseng total saponins (GTS) purified from the water extract of KRG were administered orally to mice. One hour atier administration of KRG water extract and GTS, mice were tested on the elevated plus-maze. The water extract of KRG 100 mglkg. and GTS 25 and 50 mglkg did not increase open ann entries and time spent on open arms. However. GTS 100 mg/kg increased the number of open arm entries and time spent on open arms. On the other hand. as the plus-maze test was affected by changes in locomotor activity. an additional test was can'ied out with the specific aim of monitoring locomotor activity. The water extract of KRG 100 mg/kg, and GTS 25 and 50 mglkg did not affect the locomotor activity. However. GTS 100 mglkg significantly decreased locomotor activity. From this study. we suggest that GTS may play an impoitant role on the anx-iolytic effects in the plus-maze model.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGMENT
REFERENCE
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UCI(KEPA) : I410-ECN-0101-2009-524-014303971