지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.4
- 수록면
- 210 - 218 (9page)
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초록· 키워드
오류제보하기
Numerous studies have suggested that Korean red ginseng (KRG) extract has various immune modulatory activities both in vivo and in vitro. In this study, we used a mouse model to examine the effects of orally administered KRG extract on immunity against herpes simplex virus (HSV). Balb/c mice were administered with 100, 200, and 400 mg/kg oral doses of KRG extract for 10 d and then vaginally infected with HSV. We found that KRG extract rendered recipients more resistant against HSV vaginal infection and further systemic infection, including decreased clinical severity, increased survival rate, and accelerated viral clearance. Such results appeared to be mediated by increased vaginal IFN-γ secretion. Moreover, increased mRNA expression of IFN-γ, granzyme B, and Fas-ligand was identified in the iliac lymph node and vaginal tracts of KRG extract treated groups (200 and 400 mg/kg). These results suggest that the activities of local natural killer cells were promoted by KRG extract consumption and that KRG may be an attractive immune stimulator for helping hosts overcome HSV infection.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Eo SK / 2001 / Modulation of immunity against herpes simplex virus infection via mucosal genetic transfer of plasmid DNA encoding chemokines / J Virol 75 : 569 ~ 578
2. [학술지(정기간행물)] - Bird L. / 2008 / Mucosal vaccines: NKT cells help fight flu / Nat Rev Immunol 8 : 402 ~ 403
3. [학술지(정기간행물)] - Johnson AJ / 2008 / Effector CD4+ T-cell involvement in clearance of infectious herpes simplex virus type 1 from sensory ganglia and spinal cords / J Virol 82 : 9678 ~ 9688
4. [학술지(정기간행물)] - Kuklin N / 1997 / Induction of mucosal immunity against herpes simplex virus by plasmid DNA immunization / J Virol 71 : 3138 ~ 3145
5. [학술지(정기간행물)] - Kwant-Mitchell A / 2009 / Mucosal innate and adaptive immune responses against herpes simplex virus type 2 in a humanized mouse model / J Virol 83 : 10664 ~ 10676
2. [학술지(정기간행물)] - Bird L. / 2008 / Mucosal vaccines: NKT cells help fight flu / Nat Rev Immunol 8 : 402 ~ 403
3. [학술지(정기간행물)] - Johnson AJ / 2008 / Effector CD4+ T-cell involvement in clearance of infectious herpes simplex virus type 1 from sensory ganglia and spinal cords / J Virol 82 : 9678 ~ 9688
4. [학술지(정기간행물)] - Kuklin N / 1997 / Induction of mucosal immunity against herpes simplex virus by plasmid DNA immunization / J Virol 71 : 3138 ~ 3145
5. [학술지(정기간행물)] - Kwant-Mitchell A / 2009 / Mucosal innate and adaptive immune responses against herpes simplex virus type 2 in a humanized mouse model / J Virol 83 : 10664 ~ 10676
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UCI(KEPA) : I410-ECN-0101-2014-520-003018768