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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.9
- 수록면
- 96 - 107 (12page)
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초록· 키워드
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The purpose of this study was to assess the single and 5 week oral dose toxicity of
calcitriol and alendronate combination (1 : 10,000) treatment for osteoporosis or Paget's disease in
male and female rats. In single dose oral toxicity study, the values of LD50 of calcitriol and alendronate
mixture were 750.075 mg/kg in male rats and 775.0775 mg/kg in female rats, respectively.
Body weight and food consumption were continuously increased after adminstration of calcitriol and
alendronate mixtures, and there was no significant changes in body weight and food consumption in
all groups. In five-week oral toxicity study of calcitriol and alendronate mixture at a dose of 0.2 μg +
2 mg, 1 μg + 10 mg, 5 μg + 50 mg and 25 μg + 250 mg, respectively, there was no mortality,
abnormal behavior and appearance in all groups throughout the administration period (5 weeks) and
recovery period (2 weeks). Dose-dependent changes in parameters of urinalysis and hematological
analysis were not observed in male and female rats treated with calcitriol and alendronate mixtures.
All the values of the parameters appeared to be in the normal range. These data indicate that both
calcitriol and alendronate are drugs having low toxicity in rats. NOAEL of calcitriol and alendronate
mixtures were 50.005 mg/kg in 5-week oral toxicity.
calcitriol and alendronate combination (1 : 10,000) treatment for osteoporosis or Paget's disease in
male and female rats. In single dose oral toxicity study, the values of LD50 of calcitriol and alendronate
mixture were 750.075 mg/kg in male rats and 775.0775 mg/kg in female rats, respectively.
Body weight and food consumption were continuously increased after adminstration of calcitriol and
alendronate mixtures, and there was no significant changes in body weight and food consumption in
all groups. In five-week oral toxicity study of calcitriol and alendronate mixture at a dose of 0.2 μg +
2 mg, 1 μg + 10 mg, 5 μg + 50 mg and 25 μg + 250 mg, respectively, there was no mortality,
abnormal behavior and appearance in all groups throughout the administration period (5 weeks) and
recovery period (2 weeks). Dose-dependent changes in parameters of urinalysis and hematological
analysis were not observed in male and female rats treated with calcitriol and alendronate mixtures.
All the values of the parameters appeared to be in the normal range. These data indicate that both
calcitriol and alendronate are drugs having low toxicity in rats. NOAEL of calcitriol and alendronate
mixtures were 50.005 mg/kg in 5-week oral toxicity.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
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