지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 263 - 268 (6page)
이용수
초록· 키워드
오류제보하기
The aim of this study was to investigate the acute oral toxicity of fermented Scutellariae Radix (JKTMHGu- 100) in rats and dogs. JKTM-HGu-100 was orally administered at a dose of 2,000 mg/kg in Sprague-Dawley rats. An escalating single-dose oral toxicity test in beagle dogs was performed at doses of 500, 1000, and 2000 mg/kg with 4-day intervals. Clinical signs, changes in body weight, mortality, and necropsy findings were examined for 2 weeks following oral administration. No toxicological changes related to the test substance nor mortality was observed after administration of a single oral dose of JKTM-HGu-100 in rats or dogs. Therefore, the approximate lethal dose (LD) for oral administration of JKTMHGu-100 in rats was considered to be over 2,000 mg/kg, and the maximum tolerance doses (MTDs) in rats and dogs were also estimated to be over 2,000 mg/kg. These results indicate that JKTM-HGu-100 shows no toxicity in rodents or non-rodents at doses of 2,000 mg/kg or less.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (32)
참고문헌 신청
Blaut, M / 2007 / Metabolic diversity of the intestinal microbiota: implications for health and disease / J. Nutr 137:751~755
Chan, K. / 2000 / Examples of interactions between Chinese herbal medicinal products and orthodox drug, In Interactions between Chinese Herbal Medicinal Products and Orthodox Drugs / Harwood Academic Publishers :57~97
Chan, H.M / 1987 / Pharmacology and Applications of Chinese Materia Medica / World Scientific :1022~1028
Chau, C.F / 2006 / The development of regulations of Chinese herbal medicines for both medicinal and food uses / Trends Food Sci. Tech 17:313~323
Cheigh, H.S / 1994 / Biochemical, microbiological, and nutritional aspects of Kimchi (Korean femented vegetable and products) / Crit. Rev. Food Sci. Nutr 34:175~203
Chan, K. / 2000 / Examples of interactions between Chinese herbal medicinal products and orthodox drug, In Interactions between Chinese Herbal Medicinal Products and Orthodox Drugs / Harwood Academic Publishers :57~97
Chan, H.M / 1987 / Pharmacology and Applications of Chinese Materia Medica / World Scientific :1022~1028
Chau, C.F / 2006 / The development of regulations of Chinese herbal medicines for both medicinal and food uses / Trends Food Sci. Tech 17:313~323
Cheigh, H.S / 1994 / Biochemical, microbiological, and nutritional aspects of Kimchi (Korean femented vegetable and products) / Crit. Rev. Food Sci. Nutr 34:175~203
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UCI(KEPA) : I410-ECN-0101-2014-513-000614645