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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 33 - 40 (8page)
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Purpose: This study aimed to investigate whether Müllerian inhibiting substance (MIS) in combination with calcitriol modulates proliferation and apoptosis of human ovarian cancer (OCa) cell lines (SKOV3, OVCAR3, and OVCA433) and identify the signaling pathway by which MIS mediates apoptosis.
Materials and Methods: OCa cell lines were treated with MIS in the absence or presence of calcitriol. Cell viability and proliferationwere evaluated using the Cell Counting Kit-8 assay and apoptosis was evaluated by DNA fragmentation assay. Western blot and enzyme-linked immunosorbent assay were used to determine the signaling pathway.
Results: The cells showed specific staining for the MIS type II receptor. Treatment of OCa cells with MIS and calcitriol led to dose- and time-dependent inhibition of cell growth and survival. The combination treatment significantly suppressed cell growth, down-regulated the expression of B-cell lymphoma 2 (Bcl-2), and up-regulated the expressions of Bcl-2 associated X protein, caspase-3, and caspase-9 through the extracellular signal-regulated kinase signaling pathway.
Conclusion: These results, coupled with a much-needed decrease in the toxic side effects of currently employed therapeutic agents, provide a strong rationale for testing the therapeutic potential of MIS, alone or in combination with calcitriol, in the treatmentof OCa.
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참고문헌 (25)
참고문헌 신청
Barbie TU / 2003 / Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107 / Proc Natl Acad Sci U S A 100 : 15601 ~ 15606
Berkenblit A / 2005 / Advances in the management of epithelial ovarian cancer / J Reprod Med 50 : 426 ~ 438
Coughlin JP / 1987 / Mullerian inhibiting substance blocks autophosphorylation of the EGF receptor by inhibiting tyrosine kinase / Mol Cell Endocrinol 49 : 75 ~ 86
Giammanco M / 2015 / Vitamin D in cancer chemoprevention / Pharm Biol 53 : 1399 ~ 1434
Gocek E / 2009 / Vitamin D and differentiation in cancer / Crit Rev Clin Lab Sci 46 : 190 ~ 209
Berkenblit A / 2005 / Advances in the management of epithelial ovarian cancer / J Reprod Med 50 : 426 ~ 438
Coughlin JP / 1987 / Mullerian inhibiting substance blocks autophosphorylation of the EGF receptor by inhibiting tyrosine kinase / Mol Cell Endocrinol 49 : 75 ~ 86
Giammanco M / 2015 / Vitamin D in cancer chemoprevention / Pharm Biol 53 : 1399 ~ 1434
Gocek E / 2009 / Vitamin D and differentiation in cancer / Crit Rev Clin Lab Sci 46 : 190 ~ 209
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